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临床前CDMO研发化合物筛选
lurasidone
中文名称:鲁拉西酮
CAS号:367514-87-2
分子式: C28H36N4O2S 分子量: 492.68
产品形式: free base
研发状态: Completed
研发用途: Schizophrenia
研究机构: Sumitomo Pharma America Inc.
研发日期: June 7 2018
研发阶段: Phase 1
Lurasidone (SM-13496) is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.
Rivaroxaban (BAY 59-7939)
中文名称:利伐沙班
CAS号:366789-02-8
分子式: C19H18ClN3O5S 分子量: 435.88
产品形式: free base
研发状态: Not yet recruiting
研发用途: Prevention of Venous Thromboembolism; Congenital Heart Disease; Fontan Procedure; Children
研究机构: Bayer; Janssen Research & Development LLC
研发日期: May 31 2024
研发阶段: --
Rivaroxaban (BAY 59-7939) is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20 μM).
Procarbazine HCl
中文名称:盐酸甲基苄肼
CAS号:366-70-1
分子式: C12H19N3O.HCl 分子量: 257.76
产品形式: Hydrochloride
研发状态: Withdrawn
研发用途: Brain and Central Nervous System Tumors
研究机构: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
研发日期: Phase 3
研发阶段:
Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.
Mubritinib (TAK 165)
中文名称:木利替尼
CAS号:366017-09-6
分子式: C25H23F3N4O2 分子量: 468.47
产品形式: free base
研发状态: Completed
研发用途: Breast Neoplasm; Pancreatic Neoplasm; Lung Neoplasm; Ovarian Neoplasm; Renal Neoplasm
研究机构: Takeda
研发日期: Jun-02
研发阶段: Phase 1
Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM in BT-474 cell; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk in BT-474 cell line.
Diazoxide
中文名称:氯甲苯噻嗪
CAS号:364-98-7
分子式: C8H7ClN2O2S 分子量: 230.67
产品形式: free base
研发状态: Active not recruiting
研发用途: Congenital Hyperinsulinism
研究机构: Zealand Pharma
研发日期: May 1 2019
研发阶段: Phase 3
Diazoxide (Sch-6783, SRG-95213, Proglycem) is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.
Cinacalcet (AMG-073) HCl
中文名称:盐酸西那卡塞
CAS号:364782-34-3
分子式: C22H22F3N.HCl 分子量: 393.87
产品形式: Hydrochloride
研发状态: Completed
研发用途: Drug Effect
研究机构: Tanta University
研发日期: August 5 2023
研发阶段: Phase 4
Cinacalcet (Mimpara, Sensipar,AMG-073) HCl represents a new class of compounds for the treatment of hyperparathyroidism.
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