项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Tiprenolol hydrochloride, DU-21445

1-(异丙吡酯)-3-[2-(甲基磺基)苯氧基]丙烷-2-醇盐酸盐替普洛尔 Chemical Name: 1-(Isopropylamino)-3-[2-(methylsulfanyl)phenoxy]propan-2-ol hydrochloride
CAS No. 39832-43-4, 26481-51-6 (free base)
项目整合开发状态: Biological Te...
参考文献标题:Tiprenolol hydrochloride
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Weetman,D.F.
参考来源:Drugs Fut 1979,4(11),830

NSC-364432, SarCNU

1-(氨甲酰甲基)-3-(2-氯乙基)-1-甲基-3-硝基酸盐Chemical Name: 1-(Carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitrosourea; N2-[N-(2-Chloroethyl)-N-nitrosocarbamoyl]sarcosinamide
CAS No. 81965-43-7
项目整合开发状态: Ph...
参考文献标题:Nitrosourea derivs.
文献作者:Suami,T.
参考来源:US 4452814

G25

1,1'-(六氟烷-1,16-二基)双(1-甲基吡咯里铀)二溴化物Chemical Name: 1,1'-(Hexadecane-1,16-diyl)bis(1-methylpyrrolidinium) dibromide
CAS No. 201849-42-5
项目整合开发状态: Preclinical
项目研究机构: CNRS (Originator), Universit?...
参考文献标题:Antimalarial and anti-babesiosis agents and pharmaceutical compsns.containing same
文献作者:Vial,H.; Calas,M.; Ancelin,M.-L.; Giral,L.
参考来源:FR 2751967; WO 9804252

BN-81674

1,1-二戊基-3(R)-(4-苯基-1H-吡唑-2-基)-2,3,4,9-四氢-1H-β-羧Chemical Name: 1,1-Dipentyl-3(R)-(4-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-beta-carboline; 1,1-Dipentyl-3(R)-(4-phenyl-1H-imidazol-2-yl)-2,3,4,9-...
参考文献标题:Identification of potent non-peptide somatostatin antagonists with sst3 selectivity
文献作者:Poitout,L.; Roubert,P.; Contour-Galcera,M.O.; Moinet,C.; Lannoy,J.; Pommier,J.; Plas,P.; Bigg,D.; Thurieau,C.
参考来源:J Med Chem 2001,44(18),2990

新产品编号:979767

1,1-二氯-2,3-二苯基环丙烷Chemical Name: cis-1,1-Dichloro-2,3-diphenylcyclopropane; cis-1,1'-(3,3-Dichloro-1,2-cyclopropanediyl)bisbenzene
CAS No. 59130-21-1
项目整合开发状态: Preclinical
项目研究机构: University o...
参考文献标题:Synthesis and biological evaluation of a series of gem-dichlorocyclopropanes as antitumor agents
文献作者:Griffin,M.T.; et al.
参考来源:Anti-Cancer Drug Des 1992,7(1),49

Dexanabinone, Dexanabinol, PRS-211007, HU-211

1,1-二甲基庚基-11-羟基四氢大麻酚Chemical Name: (+)-7-Hydroxy-DELTA6-tetrahydrocannabinol dimethylheptyl homolog; (+)-(S,S)-6,6-Dimethyl-(1,1-dimethylheptyl)-1-hydroxy-9-(hydroxymethyl)-6a,7,10,10a-tetrahydro-6H-d...
参考文献标题:Synthesis of deuterated dexanabinol,a nonpsychotropic cannabinoid with neuroprotective properties
文献作者:Pop,E.; et al.
参考来源:J Label Compd Radiopharm 1998,41(10),885

Isoguvacine

1,2,3,6-四氢-吡啶-4-羧酸盐酸盐Chemical Name: 1,2,3,6-Tetrahydropyridine-4-carboxylic acid
CAS No. 64603-90-3
项目整合开发状态: Preclinical
项目研究机构: University of Arizona (Originator)
合成路线:The alcoholysis of...
参考文献标题:Chemistry and pharmacology of the GABA agonists THIP (Gabodaxol) and isoguvacine
文献作者:Christensen,V.; Krogsgaard-Larsen,P.; Falch,E.
参考来源:Drugs Fut 1984,9(8),597

Doranidazole, PR-000350, PR-350, RP-343

1,2,4-丁烯醇,3-[(2-硝基-1H-吡达唑-1-酰基)甲氧基]-, (2R,3S)-rel-Chemical Name: (?-1-[2,3-Dihydroxy-1-(hydroxymethyl)propoxymethyl]-2-nitroimidazole; (?-(2RS,3SR)-3-(2-Nitro-1H-imidazol-1-ylmethoxy)butane-1,2,4-trio...
参考文献标题:2-Nitroimidazole deriv.,production thereof,and radiosensitizer containing the same as active ingredient
文献作者:Suzuki,T.; Sakaguchi,M.; Miyata,Y.; Suzuki,A.; Mori,T.(Pola Chemical Industries Inc.)
参考来源:EP 0513351; JP 1991223258; US 5270330; WO 9111440

Olprinone hydrochloride, Loprinone hydrochloride, E-1020, Coretec

1,2-二氢-5-咪唑并[1,2-a]吡啶-6-基-6-甲基-2-氧代-3-吡啶甲腈盐酸盐奥普力农 Chemical Name: 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile hydrochloride monohydrate
CAS No. 119615-63-3 (anh...
参考文献标题:5-(6-Imidazo[1,2-a]pyridyl)pyridine derivs.
文献作者:Miyake,K.; Ohhara,H.; Suda,S.; Toshiaki,O.; Yamanaka,M.(Eisai Co.,Ltd.)
参考来源:EP 0199127; ES 8706146; ES 8708230; ES 8708231; ES 8801654; ES 8801655; JP 1986218589; US 4751227

VNP-40101M, 101M, Cloretazine

1,2-双(甲磺酰基)-1-(2-氯乙基)-2-(甲氨羰基)肼Chemical Name: 1-(2-Chloroethyl)-4-methyl-1,2-bis(methylsulfonyl)semicarbazide
CAS No. 173424-77-6
项目整合开发状态: Phase II
项目研究机构: Vion (Orphan Drug), Yale Universit...
参考文献标题:Antitumor 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-(substd.)hydrazines
文献作者:Satorelli,A.C.; Shyam,K.; Penketh,P.G.(Yale University)
参考来源:EP 0841912; JP 1999508898; WO 9702029