G25
1,1'-(六氟烷-1,16-二基)双(1-甲基吡咯里铀)二溴化物Chemical Name: 1,1'-(Hexadecane-1,16-diyl)bis(1-methylpyrrolidinium) dibromide
CAS No. 201849-42-5
项目整合开发状态: Preclinical
项目研究机构: CNRS (Originator), Universit?Montpellier II (Originator)
合成路线:The title bis-ammonium salt is obtained by quaternization of N-methyl pyrrolidine (II) with 1,16-dibromohexadecane (I) in refluxing EtOH.
📌 参考资料/链接：
参考文献标题:Antimalarial and anti-babesiosis agents and pharmaceutical compsns.containing same
文献作者:Vial,H.; Calas,M.; Ancelin,M.-L.; Giral,L.
参考来源:FR 2751967; WO 9804252
📄 详细内容
合成路线:The title bis-ammonium salt was prepared by quaternization of triethylamine (II) with 1,21-dibromoeicosane (I) in refluxing EtOH.
合成路线:The title bis-ammonium salt is obtained by quaternization of N-methyl pyrrolidine (II) with 1,16-dibromohexadecane (I) in refluxing EtOH.
参考文献标题:Antimalarial activity of compounds interfering with Plasmodium falciparum phospholipid metabolism: Comparison between mono- and bisquaternary ammonium salts
文献作者:Calas,M.; Ancelin,M.L.; Cordina,G.; Portefaix,P.; Piquet,G.; Vidal-Sailhan,V.; Vial,H.
参考来源:J Med Chem 2000,43(3),505
产品链接: CAS No. 201849-42-5››