Tiprenolol hydrochloride, DU-21445
1-(异丙吡酯)-3-[2-(甲基磺基)苯氧基]丙烷-2-醇盐酸盐 替普洛尔 Chemical Name: 1-(Isopropylamino)-3-[2-(methylsulfanyl)phenoxy]propan-2-ol hydrochloride
CAS No. 39832-43-4, 26481-51-6 (free base)
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The condensation of o-(methylthio)phenol (I) with epichlorohydrin (II) by means of sodium hydroxide in water gives 3-[o-(methylthio)phenoxy]-1,2-epoxypropane (III),which is then treated with isopropylamine (IV) in hot water and finally with ethanolic HCl
📌 参考资料/链接：
参考文献标题:Tiprenolol hydrochloride
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Weetman,D.F.
参考来源:Drugs Fut 1979,4(11),830
📄 详细内容
合成路线:The condensation of o-(methylthio)phenol (I) with epichlorohydrin (II) by means of sodium hydroxide in water gives 3-[o-(methylthio)phenoxy]-1,2-epoxypropane (III),which is then treated with isopropylamine (IV) in hot water and finally with ethanolic HCl
参考文献标题:
文献作者:(N.V.Philips' Gloeilampenfabrieken)
参考来源:BE 679005; CA 832495; DE 1543790; FR 1552786; FR 6393; GB 1137764; JP 6902978; NL 6504268; US 3542874; US 3632780
产品链接: CAS No. 39832-43-4›› 产品链接: CAS No.26481-51-6››