BN-81674

1,1-二戊基-3(R)-(4-苯基-1H-吡唑-2-基)-2,3,4,9-四氢-1H-β-羧Chemical Name: 1,1-Dipentyl-3(R)-(4-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-beta-carboline; 1,1-Dipentyl-3(R)-(4-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
CAS No. 252278-73-2
项目整合开发状态: Biological Testing
项目研究机构: Institut Henri Beaufour (Originator)
合成路线:Phenacyl ester (III) was prepared by treatment of the cesium salt of N-Boc-tryptophan (I) with 2-bromoacetophenone (II) in DMF.Cyclization of keto ester (III) with ammonium acetate in refluxing xylene yielded the target imidazole (IV).Acidic Boc group deprotection of (IV) then gave amine (V).Finally,Pictet-Spengler cyclization of (V) with 6-undecanone (VI) provided the desired tetrahydrocarboline.