项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:486183

Chemical Name: 3-Cyano-4-hydroxy-N'-[4-(4-isopropylbenzyloxy)-3,5-dimethoxybenzylidene]benzohydrazide
CAS No. 219681-70-6
项目整合开发状态: Preclinical
项目研究机构: Anadys (Originator), Novo Nordisk (Orig...
参考文献标题:Glucagon antagonists/inverse agonists
文献作者:Gonzales,J.; Sams,C.; Teng,M.(Alanex Corp.; Novo Nordisk A/S)
参考来源:EP 0994848; WO 9901423

DIBRT

Chemical Name: 3,5-Dibromo-4-(4-hydroxy-3,5-diisopropylphenoxy)benzoic acid
CAS No. 192766-84-0
项目整合开发状态: Biological Testing
项目研究机构: Karo Bio (Originator), University of California, San Franc...
参考文献标题:Nuclear receptor ligands and ligand binding domains
文献作者:Brenneisen,P.; et al.(Ciba Geigy Corp.)
参考来源:DE 1932690; DE 1935338; US 3839582

BILS-103BS

Chemical Name: N-[2-[4-(2-Amino-1,3-thiazol-4-yl)phenylamino]-2-oxoethyl]-N-(pyridin-4-ylmethyl)cyclohexanecarboxamide
CAS No. 193346-57-5
项目整合开发状态: Preclinical
项目研究机构: Boehringer Ingelheim (...
参考文献标题:Phenyl thiazole derivs.with anti-herpes virus properties
文献作者:Hargrave,K.D.; Simoneau,B.; Faucher,A.-M.; Thavonekham,B.; Grygon,C.A.; Crute,J.J.(Boehringer Ingelheim (Canada) Ltd.; Boehringer Ingelheim Pharmaceuticals Inc.)
参考来源:EP 0871619; JP 2000502702; US 6057451; WO 9724343

PQ

Chemical Name: Acetic acid 2,6-dimethoxy-4-(9-oxo-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ylidenemethyl)phenyl ester
CAS No. 371766-68-6
项目整合开发状态: Preclinical
项目研究机构: Universidad de Murc...
参考文献标题:Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives
文献作者:Molina,P.; Tarraga,A.; Gonzalez-Tejero,A.; Rioja,I.; Ubeda,A.; Terencio,M.C.; Alcaraz,M.J.
参考来源:J Nat Prod 2001,64(10),1297

CC-3

Chemical Name: 6-Ethyl-3-methyl-4-phenyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-one
CAS No. 189307-02-6
项目整合开发状态: Biological Testing
项目研究机构: Forschungszentrum Borstel (Originator), Univers...
参考文献标题:Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors
文献作者:Dal Piaz,V.; Giovannoni,M.P.; Castellana,C.; Palacios,J.M.; Beleta,J.; Domenech,T.; Segarra,V.
参考来源:J Med Chem 1997,40(10),1417

新产品编号:36895

Chemical Name: (5R,6S)-6-[1(R)-Hydroxyethyl]-3-[1-(methyliminomethyl)pyrrolidin-3(S)-yl]-1-carbapen-2-em-3-carboxylic acid
CAS No. 132947-63-8, 133006-76-5 (diastereomer)
项目整合开发状态: Preclinical 参考文献标题:1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid cpds.
文献作者:Murata,M.; Chiba,T.; Tsutsumi,H.; Hattori,K.; Kuroda,S.; Ohtake,H.; Shirai,F.(Fujisawa Pharmaceutical Co.,Ltd.)
参考来源:EP 0394991; JP 1990300187; US 5102877

新产品编号:693425

Chemical Name: 4-[2-[2-[3-(Biphenyl-4-yl)-5-methyl-4H-1,2,4-triazol-4-yl]phenoxy]ethyl]morpholine
CAS No. 258878-68-1
项目整合开发状态: Biological Testing
项目研究机构: Yamanouchi (Originator)
合成路线:The ...
参考文献标题:Novel triazole derivs.
文献作者:Suzuki,T.; Murakami,T.; Tobe,T.; Tahara,A.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:WO 0158880

新产品编号:880101

Chemical Name: 9-(3,3-Diphenyl-2-propenyl)-3-propionyl-3,9-diazabicyclo[3.3.1]nonane
CAS No. 355004-85-2 (monoHCl)
项目整合开发状态: Preclinical
项目研究机构: Cent Consortile Ric Neuropsicofarmacol (Origin...
参考文献标题:3,9-Diazabicyclo[3.3.1]nonane derivs.with analgesic activity
文献作者:Cignarella,G.; Pinna,G.A.(Centro Consortile Ricerche Neuropsicofarmacologiche a.r.l)
参考来源:EP 1259511; WO 0160823

CP-409069

Chemical Name: (2R,4aS,10aR)-4a-Benzyl-2-(1-propynyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-2,7-diol
CAS No. 305822-65-5, 305822-66-6 (diastereomer), 305824-23-1 (diastereomer), 305822-40-6 (st...
参考文献标题:Glucocorticoid receptor modulators
文献作者:Liu,K.K.-C.; Morgan,B.P.; Dow,R.L.; Swick,A.G.(Pfizer Inc.)
参考来源:EP 1175383; WO 0066522

YM-176770

Chemical Name: 1-[6-[2-[3-(4-Biphenylyl)-5-methyl-4H-1,2,4-triazol-4-yl]phenoxy]hexyl]-4-methylpiperazine
CAS No. 258878-50-1
项目整合开发状态: Preclinical
项目研究机构: Yamanouchi (Originator)
合成路线:Ace...
参考文献标题:Synthesis and pharmacological evaluation of 5-(4-biphenyl)-3-methyl-4-phenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human vasopressin V1A receptor
文献作者:Kakefuda,A.; Suzuki,T.; Tobe,T.; Tsukada,J.; Tahara,A.; Sakamoto,S.; Tsukamoto,S.
参考来源:J Med Chem 2002,45(12),2589