新产品编号:880101
Chemical Name: 9-(3,3-Diphenyl-2-propenyl)-3-propionyl-3,9-diazabicyclo[3.3.1]nonane
CAS No. 355004-85-2 (monoHCl)
项目整合开发状态: Preclinical
项目研究机构: Cent Consortile Ric Neuropsicofarmacol (Originator), Universit?degli Studi di Cagliari (Originator), Universit?degli Studi di Milano (Originator), Universit?degli Studi di Sassari (Originator)
合成路线:Horner-Emmons condensation of benzophenone (I) with triethyl phosphonoacetate provides the unsaturated ester (II),which is further reduced with DIBAL in toluene to the allylic alcohol (III).Reaction of alcohol (III) with methanesulfonyl chloride and Et3N leads to chloride (IV).Finally,alkylation of 3-propionyl-3,9-diazabicyclo[3.3.1]nonane (V) with the allyl chloride (IV) furnishes the title compound.
📌 参考资料/链接：
参考文献标题:3,9-Diazabicyclo[3.3.1]nonane derivs.with analgesic activity
文献作者:Cignarella,G.; Pinna,G.A.(Centro Consortile Ricerche Neuropsicofarmacologiche a.r.l)
参考来源:EP 1259511; WO 0160823
📄 详细内容
合成路线:Horner-Emmons condensation of benzophenone (I) with triethyl phosphonoacetate provides the unsaturated ester (II),which is further reduced with DIBAL in toluene to the allylic alcohol (III).Reaction of alcohol (III) with methanesulfonyl chloride and Et3N leads to chloride (IV).Finally,alkylation of 3-propionyl-3,9-diazabicyclo[3.3.1]nonane (V) with the allyl chloride (IV) furnishes the title compound.
参考文献标题:N-3(9)-Arylpropenyl-N-9(3)-propionyl-3,9-diazabicyclo[3.3.1]nonanes as mu-opioid receptor agonists.Effects on mu-affinity of arylalkenyl chain modifications
文献作者:Pinna,G.A.; Cignarella,G.; Loriga,G.; Murineddu,G.; Mussinu,J.-M.; Ruiu,S.; Fadda,P.; Fratta,W.
参考来源:Bioorg Med Chem 2002,10(6),1929