CC-3
Chemical Name: 6-Ethyl-3-methyl-4-phenyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-one
CAS No. 189307-02-6
项目整合开发状态: Biological Testing
项目研究机构: Forschungszentrum Borstel (Originator), Universit?degli Studi di Firenze (Originator)
合成路线:Cyclization of ethyl 4-benzoyl-5-methylisoxazole-3-carboxylate (I) with hydrazine hydrate affords the isoxazolopyridazinone (II).Regioselective alkylation of (II) with ethyl bromide gives the 6-ethyl derivative (III).This is then subjected to oxidative isoxazole ring cleavage with cerium ammonium nitrate to furnish the nitro ketone (IV).Finally,cyclization of (IV) with ethanolic hydrazine leads to the target pyrazolopyridazinone.
📌 参考资料/链接：
参考文献标题:Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors
文献作者:Dal Piaz,V.; Giovannoni,M.P.; Castellana,C.; Palacios,J.M.; Beleta,J.; Domenech,T.; Segarra,V.
参考来源:J Med Chem 1997,40(10),1417