项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

BL-3875

Chemical Name: N-(3,5-Dimethylisoxazol-4-ylcarbonyl)-L-valyl-L-proline 1(S)-(1-benzothien-3-ylmethyl)-3,3,3-trifluoro-2-oxopropylamide
CAS No. 402732-26-7
项目整合开发状态: Preclinical
项目研究机构: Dainip...
参考文献标题:Pyrrolidine derivs.and their use as chymase inhibitor
文献作者:Sato,F.; Showell,G.A.; Fujitani,B.; Deguchi,T.; Honda,Y.; Shiratake,R.; Kiyoshi,A.; Notake,M.; Boyle,R.G.; Klair,S.S.(Dainippon Pharmaceutical Co.,Ltd.)
参考来源:WO 0218378

BL-4027

Chemical Name: N-(4-Methyl-1,2,3-thiadiazol-5-ylcarbonyl)-L-valyl-L-proline 1(S)-(1-benzothien-3-ylmethyl)-3,3,3-trifluoro-2-oxopropylamide
CAS No. 402732-45-0
项目整合开发状态: Preclinical
项目研究机构: D...
参考文献标题:Pyrrolidine derivs.and their use as chymase inhibitor
文献作者:Sato,F.; Showell,G.A.; Fujitani,B.; Deguchi,T.; Honda,Y.; Shiratake,R.; Kiyoshi,A.; Notake,M.; Boyle,R.G.; Klair,S.S.(Dainippon Pharmaceutical Co.,Ltd.)
参考来源:WO 0218378

新产品编号:861117

Chemical Name: 4(S)-[3-(3,4-Difluorophenyl)-2(S)-[3-(5-methylisoxazol-3-ylcarboxamido)-2-oxo-1,2-dihydropyridin-1-yl]propionamido]-5-[2-oxopyrrolidin-3(S)-yl]-2(E)-pentenoic acid isopropyl ester
CA...
参考文献标题:Antipicornaviral cpds.and compsns.,their pharmaceutical uses,and material for their synthesis
文献作者:Dragovich,P.S.; Prins,T.J.; Zhou,R.; Johnson,T.O.Jr.(Agouron Pharmaceuticals,Inc.)
参考来源:JP 2003515591; US 2001047006; US 6514997; WO 0140189

PD-205520

Chemical Name: N-[4-(3-Chloro-4-fluorophenylamino)pyrido[3,4-d]pyrimidin-6-yl]-5-(4-methylpiperazin-1-yl)-2-pentynamide hydrochloride
CAS No. 198960-77-9 (free base)
项目整合开发状态: Preclinical
项目研...
参考文献标题:Irreversible inhibitors of tyrosine kinases
文献作者:Dobrusin,E.M.; Bridges,A.J.; Zhou,H.; Smaill,J.B.; Doherty,A.M.; Denny,W.A.; McNamara,D.J.; Showalter,H.D.(Pfizer Inc.)
参考来源:JP 2000508657; WO 9738983

LY-487355

Chemical Name: N-[(1R,3S)-3-[9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl]cyclohexylmethyl]-6-fluoropyridine-3-carboxamide
CAS No. 347181-26-4, 347179-31-1 (undefined isomer)
项目整合开发状...
参考文献标题:Methods and cpds.for inhibiting MRP1
文献作者:Jungheim,L.N.; Kroin,J.S.; Bonjouklian,R.; Thrasher,K.J.; Norman,B.H.; Muehl,B.S.; Patel,V.F.; Richett,M.E.; Gruber,J.M.; Lin,H.-S.; Cohen,J.D.; Wang,Q.; Xie,Y.; Johnson,D.W.; Lander,P.A.; Lohman,M.C.; et al.(Eli Lilly and Company)
参考来源:EP 1250340; WO 0146199

A-422885.66, BSF-466895

Chemical Name: N-[4-[4-Amino-7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-fluorophenyl]-2,3-dichlorobenzenesulfonamide
CAS No. 262442-90-0, 262443-26-5 (cis-iso...
参考文献标题:Pyrrolopyrimidines as protein kinase inhibitors
文献作者:Hirst,G.C.; Ritter,K.; Arnold,L.D.; Wishart,N.; Calderwood,D.(BASF AG)
参考来源:EP 1114053; WO 0017203

BAL-8349, RO-0098349

Chemical Name: Cyclo[D-alanyl-L-tyrosyl-L-valyl-4(R)-hydroxy-L-prolyl-D-allothreonyl-L-threonyl-3(S)-hydroxy-L-prolyl-3(R)-hydroxy-L-glutaminyl-glycyl-D-allothreonyl-N-delta-(3-aminopropyl)-Ndelta-(L-...
参考文献标题:Novel cyclic cpds.
文献作者:Okada,T.; Shimma,N.; Murata,T.; Masubuchi,K.; Kohchi,M.(Basilea Pharmaceutica AG)
参考来源:EP 1254161; WO 0153322

AWD-47-222

Chemical Name: 6-(2,6-Difluorobenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one
CAS No. 402567-02-6
项目整合开发状态: Preclinical
项目研究机构: AWD.pharma (Originator)
合成路线:Condensation of lactone (I) ...
参考文献标题:6,7-Dihydro-pyrrolo[3,4-b]pyridin-5-ones with an anticonvulsive action and methods for producing the same
文献作者:Rostock,A.; Lankau,H.-J.; Unverferth,K.; Tober,C.; Rundfeldt,C.; Arnold,T.; Dost,R.; Gasparic,A.(AWD.pharma GmbH & Co.KG)
参考来源:DE 10042093; WO 0218381

Paclitaxel-SNO, NMI-1147

Chemical Name: 7-O-[3-Methyl-3-(nitrososulfanyl)butyryl]paclitaxel; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Diacetoxy-9-[3(S)-benzamido-2(R)-hydroxy-3-phenylpropionyloxy]-12-(benzoyloxy)-11-hydroxy...
参考文献标题:Nitrosated and nitrosylated taxanes,compsns.and methods of use
文献作者:Garvey,D.S.; Letts,L.G.; Wang,T.; Richardson,S.K.; Lin,C.-E.(NitroMed Inc.)
参考来源:WO 0198286

PhTX-56

Chemical Name: N1-[5-(6-Aminohexylamino)pentyl]-N2-butyryl-L-tyrosinamide bis(trifluoroacetate)
CAS No. 401601-08-9, 401601-07-8 (free base)
项目整合开发状态: Biological Testing
项目研究机构: Lundbeck (Ori...
参考文献标题:Substd.polyamine cpds.
文献作者:Usherwood,P.N.R.; Andersen,K.; Stroemgaard,K.; Jaroszewski,J.W.; Korgsgaard-Larsen,P.; Mellor,I.R.; Egebjerg,J.(H.Lundbeck A/S)
参考来源:WO 0216314