项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:867445

Chemical Name: N-(4-Methoxysuccinyl)-L-phenylalanyl-3-(methoxycarbonyl)-O-(2-methoxy-2-oxoethyl)-N-pentyl-L-tyrosinamide
CAS No. 345266-96-8
项目整合开发状态: Biological Testing
项目研究机构: Biovitrum (Or...
参考文献标题:Inhibitors of protein tyrosine phosphatase
文献作者:Bleasdale,J.; May,P.D.; Schostarez,H.J.; Barf,T.; Larsen,S.D.; Liljebris,C.(Pharmacia Corp.)
参考来源:WO 9911606

ZYC-3

Chemical Name: 2-(1-Adamantyl)-3-hydroxyestra-1,3,5(10)-trien-17-one
CAS No. 21003-01-0
项目整合开发状态: Preclinical
项目研究机构: Univ. North Texas Health Science Center (Originator), University of Flori...
参考文献标题:Modified,hydroxy-substd.aromatic structures having cytoprotective activity
文献作者:Covey,D.F.(Washington University)
参考来源:WO 0236605

新产品编号:639637

Chemical Name: 2-[4-[2-[2(R)-2-Hydroxy-2-(4-hydroxyphenyl)-1(S)-methylethylamino]ethyl]phenoxy]-2-methylpropionic acid
CAS No. 247073-88-7
项目整合开发状态: Preclinical
项目研究机构: Kissei (Originator) 参考文献标题:2-Methylpropionic acid derivs.and medicinal compsns.containing the same
文献作者:Sato,M.; Tanaka,N.; Akahane,M.; Tamai,T.; Muranaka,H.; Mukaiyama,H.; Hiribayashi,A.(Kissei Pharmaceutical Co.,Ltd.)
参考来源:EP 1072583; WO 9952856

新产品编号:925979

Chemical Name: N-[4-(beta-D-Glucopyranuronosyloxy)-3-nitrobenzyloxycarbonyl]-glycyl-L-isoleucyl-L-leucyl-glycyl-L-phenylalanyl-L-valyl-L-phenylalanyl-L-threonyl-L-leucine
CAS No. 403852-50-6
项目整...
参考文献标题:Synthesis and biological activity of the prodrug of class I major histocompatibility peptide GILGFVFTL activated by Beta-glucuronidase
文献作者:Rawale,S.; Hrihorczuk,L.M.; Wei,W.-Z.; Zemlicka,J.
参考来源:J Med Chem 2002,45(4),937

新产品编号:717155

Chemical Name: 3-[4-[2-(9H-Carbazol-9-yl)ethoxy]phenyl]-2(S)-ethoxypropionic acid arginine salt
CAS No. 265304-43-6 (free acid), 265301-03-9 (Na salt)
项目整合开发状态: Preclinical
项目研究机构: Dr. Reddy'...
参考文献标题:Novel tricyclic-alpha-alkyloxyphenylpropionic acids: Dual PPAR/gamma alpha agonists with hypolipidemic and antidiabetic activity
文献作者:Sauerberg,P.; Pettersson,I.; Jeppesen,L.; Bury,P.S.; Mogensen,J.P.; Wassermann,K.; Brand,C.L.; Sturis,J.; Woldike,H.F.; Fleckner,J.; Andersen,A.S.; Mortensen,S.B.; Svensson,L.A.; Rasmussen,H.B.; Lehmann,S.V.; Polivka,Z.; et al.
参考来源:J Med Chem 2002,45(4),789

GL-579225

Chemical Name: N,N'-Bis[5-[N-[2-(N1-methylamidino)ethyl]carbamoyl]-1-(3-methylbutyl)-1H-pyrrol-3-yl]benzene-1,4-dicarboxamide
CAS No. 386251-89-4
项目整合开发状态: Biological Testing
项目研究机构: Genelabs...
参考文献标题:Novel cpds.possessing antibacterial,antifungal or antitumor activity
文献作者:Nelson,P.H.; Muchowski,J.M.; Dyatkina,N.B.; Shi,D.-F.; Zhang,W.; Liehr,S.J.R.; Velligan,M.D.; Botyanszki,J.; Roberts,C.D.; Khorlin,A.(Genelabs Technologies,Inc.)
参考来源:WO 0200650

KF-31327

Chemical Name: 3-Ethyl-8-[2-[4-(hydroxymethyl)piperidin-1-yl]benzylamino]-2,3-dihydro-1H-imidazo[4,5-g]quinazoline-2-thione dihydrochloride
CAS No. 204077-66-7
项目整合开发状态: Biological Testing
项目...
参考文献标题:Imidazoquinazoline derivs.
文献作者:Onoda,Y.; Nomoto,Y.; Ohno,T.; Yamada,K.; Ichimura,M.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:EP 0863144; WO 9808848

新产品编号:351713

Chemical Name: 3-(Dimethylaminocarbonyloxy)-2-(2,2-diphenylpropionyloxymethyl)-1-methylpyridinium iodide
CAS No. 204850-73-7 (cation)
项目整合开发状态: Biological Testing
项目研究机构: Walter Reed Army Ins...
参考文献标题:Pyridophens: Binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase,butyrylcholinesterase,and muscarinic receptors
文献作者:Leader,H.; Wolfe,A.D.; Chiang,P.K.; Gordon,R.K.
参考来源:J Med Chem 2002,45(4),902

BIA-3-335

Chemical Name: 1-(3,4-Dihydroxy-5-nitrophenyl)-3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-one dihydrochloride
CAS No. 359783-06-5
项目整合开发状态: Preclinical
项目研究机构: Bial (Originator),...
参考文献标题:Novel substd.nitrocatechols,their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compsns.containing them
文献作者:Learmonth,D.A.; Soares Da Silva,P.M.V.A.(Portela & Ca.,SA)
参考来源:EP 1167342; WO 0198251

新产品编号:671277

Chemical Name: 2-(4'-Chlorobiphenyl-4-ylsulfanylmethyl)-4-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)butyrohydroxamic acid
CAS No. 253442-16-9
项目整合开发状态: Preclinical
项目研究机构: Servier (Originato...
参考文献标题:Carboxylic and hydroxamic acid cpds.inhibiting metalloproteases,method for preparing same and pharmaceutical compsns.containing them
文献作者:Guilbaud,N.; Atassi,G.; Le Diguarher,T.; Bonnet,J.; Sabatini,M.; Casara,P.; Chollet,A.-M.; Pierre,A.; Tucker,G.(ADIR et Cie.)
参考来源:EP 1091937; FR 2780402; WO 0000473