项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Labedipinedilol A

Chemical Name: 4-[4-[2-Hydroxy-3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-3-methoxyphenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester
CAS No. 257284-30-3
项目整合开发状态: Pre...
参考文献标题:Guaiacoxypropanolamines with alpha/beta-adrenergic blocking activity
文献作者:Lin,T.-H.; Chen,I.-J.
参考来源:EP 1108710; WO 0005209

Gadocoletic acid trisodium salt, B-22956/1

Chemical Name: Trisodium [(3beta,5beta,12alpha)-3-[4(S)-[bis[2-[bis[(carboxy-kappaO)methyl]amino-kappaN]ethyl]amino-kappaN]-4-(carboxy-kappaO)-1-oxobutylamino]-12-hydroxycholan-24-oato(6-)]gadolinate(...
参考文献标题:Blood pool agents for nuclear magnetic resonance diagnostics
文献作者:Uggeri,F.; Brocchetta,M.; Visigalli,M.; Lux,G.; De Ha雗,C.; Serleti,M.; Palano,D.; Anelli,P.L.; Lattuada,L.; Morosini,P.; Gazzotti,O.; Manfredi,G.(Bracco SpA)
参考来源:CA 2355888; EP 1140209; US 6461588; WO 0038738

新产品编号:913323

Chemical Name: (1R,5S,6S)-6-[1(R)-Hydroxyethyl]-2-[5(S)-[(E)-2-(5-isothiazolyl)vinyl]pyrrolidin-3(S)-ylsulfanyl]-1-methyl-1-carba-2-penem-3-carboxylic acid
CAS No. 387878-57-1
项目整合开发状态: Preclini...
参考文献标题:Novel 1beta-methylcarbapenem derivs.and process for preparation thereof
文献作者:Kim,D.J.; Yoo,K.H.; Kang,Y.K.; Park,S.W.; Shin,K.J.; Seo,K.J.(Korea Institute of Science and Technology)
参考来源:WO 0202561

新产品编号:750377

Chemical Name: 3-[N-[4-(4-Methylpyridin-2-ylamino)butyryl]glycylamino]-3-[4-(1-naphthyl)phenyl]propionic acid; N-[4-(4-Methylpyridin-2-ylamino)butyryl]glycyl-3-[4-(1-naphthyl)phenyl]-beta-alanine
C...
参考文献标题:beta-Alanine derivs.
文献作者:H鰈zemann,G.; Jonczyk,A.; Goodman,S.; St鋒le,W.(Merck Patent GmbH)
参考来源:WO 0048996

Ranbezolid hydrochloride, RBx-7644

Chemical Name: N-[3-[3-Fluoro-4-[4-(5-nitrofuran-2-ylmethyl)piperazin-1-yl]phenyl]-2-oxooxazolidin-5(S)-ylmethyl]acetamide monohydrochloride
CAS No. 392659-39-1, 392659-38-0 (free base)
项目整合开发状态...
参考文献标题:Oxazolidinone derivs.as antimicrobials
文献作者:Arora,S.K.; Mehta,A.; Rattan,A.; Das,B.; Ray,A.; Rudra,S.(Ranbaxy Laboratories Ltd.)
参考来源:EP 1303511; US 2002103186; WO 0206278; WO 0307870; WO 0308389

SNAP-7941

Chemical Name: (+)-3-[N-[3-[4-(3-Acetamidophenyl)piperidin-1-yl]propyl]carbamoyl]-4(S)-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester hydrochl...
参考文献标题:Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
文献作者:Gluchowski,C.; Chiu,G.; Marzabadi,M.R.; Nagarathnam,D.; Lagu,B.; Noble,S.; Wetzel,J.; Deleon,J.E.(Synaptic Pharmaceutical Corp.)
参考来源:EP 1299362; WO 0206245

BIRA-0596

Chemical Name: 2-(2,6-Dichlorophenylamino)-6,7-dimethyl-8,9-dihydro-1H-imidazo[4,5-h]isoquinolin-9-one
CAS No. 333455-11-1
项目整合开发状态: Preclinical
项目研究机构: Boehringer Ingelheim (Originator)
合...
参考文献标题:Heterocyclic cpds.useful as inhibitors of tyrosine kinases
文献作者:Goldberg,D.; Cardozo,M.G.; Tschantz,M.A.; Moss,N.; Morwick,T.; Prokopowicz,A.S.III; Snow,R.J.; Patel,U.R.; Wang,X.-J.; Hammach,A.; Takahashi,H.(Boehringer Ingelheim Pharmaceuticals Inc.)
参考来源:WO 0125238

SU-11925

Chemical Name: 4-(3-Chloro-4-fluorophenylamino)-5(Z)-[5-[3(R),5(S)-dimethylpiperazin-1-ylcarbonyl]-3-methyl-1H-pyrrol-2-ylmethylene]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-6-one
CAS No. 346600-13-3...
参考文献标题:4-Substd.7-aza-indolin-2-ones and their use as protein kinase inhibitors
文献作者:Wei,C.C.; Tang,P.C.; McMahon,G.; Sun,L.; Hirth,K.P.; Liang,C.; Cui,J.(Sugen,Inc.)
参考来源:EP 1244672; WO 0146196

AT-1459

Chemical Name: 4-[1-[2-[2(S)-[2-(6-Amidino-1-ethyl-1H-indol-2-yl)ethyl]pyrrolidin-1-yl]-2-oxoethyl]-2-oxohexahydro-1H-azepin-3(S)-ylamino]butyric acid
CAS No. 294658-50-7
项目整合开发状态: Preclinical 参考文献标题:Substd.aromatic amidine deriv.and medicinal compsn.comprising the same
文献作者:Park,C.-H.; Koo,B.-A.; Nam,W.-H.(C & C Research Laboratories)
参考来源:WO 0055156

GK-04489

Chemical Name: 5-[1-[3-[6-(2-Chlorophenyl)-1,4-methyl-7,8,9,10-tetrahydro-4H-pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-9-ylmethyl]phenyl]-1-(3-pyridyl)methylideneaminooxy]penta...
参考文献标题:Triazolo-1,4-diazepine cpds.and medicinal compsn.containing the same
文献作者:Sano,T.; Seki,T.; Fujita,M.; Inada,H.(Nikken Chemicals Co.,Ltd.)
参考来源:EP 0995752; JP 1999071378; US 6433167; WO 9858930