项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

新产品编号:916487

Chemical Name: N-(2,5-Difluorobenzyl)-4-[4-[2-[2(S)-hydroxy-3-[4-hydroxy-3-(methylsulfonamido)phenoxy]propylamino]ethyl]phenylamino]piperidine-1-carboxamide
CAS No. 392630-57-8
项目整合开发状态: Preclin...
参考文献标题:4-Aminopiperidine ureas as potent selective agonists of the human beta3-adrenergic receptor
文献作者:Ashwell,M.A.; Solvibile,W.R.Jr.; Han,S.; Largis,E.; Mulvey,R.; Tillet,J.
参考来源:Bioorg Med Chem Lett 2001,11(24),3123

GENZ-29155

Chemical Name: 2-Benzoyl-N-[1-(3-cyanophenyl)-1-[N-(2,2-diphenylethyl)carbamoylmethyl]-N-[2-(1H-imidazol-4-yl)ethyl]benzamide
CAS No. 374080-21-4, 374080-26-9 ((R)-isomer), 374080-27-0 ((S)-isomer)...
参考文献标题:Modulators of TNF-alpha signaling
文献作者:Hirth,B.H.; Sneddon,S.F.; Kane,J.L.; Vinick,F.; Qiao,S.; Nahill,S.R.(Genzyme Corp.)
参考来源:WO 0187849

新产品编号:554209

Chemical Name: (?-trans-2-[4-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]-5-methoxyindan-1-ol
CAS No. 222991-67-5, 222991-66-4 (stereoisomer)
项目整合开发状态: Preclinical
项目研究机构: Servier (Origi...
参考文献标题:Indanol derivs.,process for their preparation and pharmaceutical compsns.containing them
文献作者:Peglion,J.-L.; Millan,M.; Goument,B.; Newman-Tancredi,A.; Dekeyne,A.(ADIR et Cie.)
参考来源:CA 2249756; EP 0906912; FR 2769312; JP 1999158179; US 5958927; US 6060487

MC-1220

Chemical Name: 6-[1-(2,6-Difluorophenyl)ethyl]-2-(dimethylamino)-5-methylpyrimidin-4(3H)-one
CAS No. 391681-51-9
项目整合开发状态: Preclinical
项目研究机构: Idenix (Originator), Universit?degli Studi "La S...
参考文献标题:Selected non-nucleoside reverse transcriptase inhibitors (NNRTIs): the DABOs family
文献作者:Artico,M.
参考来源:Drugs Fut 2002,27(2),159

OJ-R9188

Chemical Name: N-(2-Tetradecylhexadecanoyl)-O-(alpha-L-fucofuranosyl)-D-seryl-L-glutamic acid methylamide L-arginine
CAS No. 190586-70-0, 190586-39-1 (free base)
项目整合开发状态: Preclinical
项目研究机构:...
参考文献标题:Studies on selectin blockers.6.Discovery of homologous fucose sugar unit necessary for E-selectin binding
文献作者:Hiramatsu,Y.; Moriyama,H.; Koyoi,T.; Tsukida,T.; Inoue,Y.; Kondo,H.
参考来源:J Med Chem 1998,41(13),2302

新产品编号:747213

Chemical Name: 1-(4-Fluorophenyl)-2-[4-(phenylsulfonyl)piperidin-1-yl]ethanone
CAS No. 285994-99-2
项目整合开发状态: Preclinical
项目研究机构: Merck Sharp & Dohme (Originator)
合成路线:The (phenylsulfanyl)p...
参考文献标题:Phenylsulphonyl derivs.as 5-HT receptor ligands
文献作者:Macleod,A.M.; Blurton,P.; Fletcher,S.R.; Van Niel,M.B.; Burkamp,F.; Cheng,S.K.-F.(Merck Sharp & Dohme Ltd.)
参考来源:EP 1147083; WO 0043362

新产品编号:49551

Chemical Name: 2-Propyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)pentanamide
CAS No. 144462-39-5
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Firenze (Originator), University of Namur (...
参考文献标题:Carbonic anhydrase inhibitors: Anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties
文献作者:Masereel,B.; Rolin,S.; Abbate,F.; Scozzafava,A.; Supuran,C.T.
参考来源:J Med Chem 2002,45(2),312

新产品编号:906995

Chemical Name: 3-[7(R)-Ethyl-2(2)-hexyl-12-[1-(heptyloxy)ethyl]-3,8(R),13,17(S)-tetramethyl-2(1),2(3)-dioxo-2(1),2(2),2(3),7,8,18-hexahydro-17H-pyrido[3,4,5-at]porphyrin-18(S)-yl]propionic acid propyl...
参考文献标题:Long wavelength absorbing bacteriochlorin alkyl ether analogs
文献作者:Pandey,R.K.; Dougherty,T.J.; Potter,W.R.(Health Research,Inc.)
参考来源:EP 1164136; JP 2002020389

DTPA-adenosylcobalamin, DAC

Chemical Name: N(b)-[4-[2-[N,N-Bis[2-[N,N-bis(carboxymethyl)amino]ethyl]amino]acetamido]butyl]-Co-(5'-deoxyadenosin-5'-yl)cobinamide f-(dihydrogen phosphate) inner salt 3'-ester with [5,6-dimethyl-1-(...
参考文献标题:Radionuclide labeling of vitamin B12 and coenzymes thereof
文献作者:Collins,D.A.; Hogenkamp,H.P.C.(Mayo Foundation for Medical Education and Research; University of Minnesota)
参考来源:WO 9718231

GM-160575

Chemical Name: (1R,3aR,4S,4aR,7R,7aR,8aS)-8a-(6-Deoxy-4-O-methyl-3-O-octanoyl-beta-D-altropyranosyloxymethyl)-4-formyl-3-isopropyl-7-methyl-1,3a,4,4a,5,6,7,7a,8,8a-decahydro-1,4-methano-s-indacene-3a-...
参考文献标题:Antifungal sordarin derivs.
文献作者:Hayes,M.; Wildman,H.; Dawson,M.; Chalk,P.; Hall,R.; Ruiz Gomez,J.R.(GlaxoSmithKline plc)
参考来源:EP 0711783; EP 0791007; JP 1999502188; US 6054478; WO 9614327