DTPA-adenosylcobalamin, DAC
Chemical Name: N(b)-[4-[2-[N,N-Bis[2-[N,N-bis(carboxymethyl)amino]ethyl]amino]acetamido]butyl]-Co-(5'-deoxyadenosin-5'-yl)cobinamide f-(dihydrogen phosphate) inner salt 3'-ester with [5,6-dimethyl-1-(alpha-D-ribofuranosyl)benzimidazole-kappa-N3]
CAS No. 191029-50-2
项目整合开发状态: Phase I
项目研究机构: Mayo Foundation (Originator), University of Minnesota (Originator), Copharos (Licensee)
合成路线:Adenosylcobalamin-b-monocarboxylic acid (I) was coupled to 1,4-butanediamine (II) in the presence of EDC and HOBt to afford the N-(4-aminobutyl)amide (III).Subsequent acylation of amino amide (III) by diethylenetriaminopentaacetic dianhydride (IV) gave rise to the title compound.
📌 参考资料/链接：
参考文献标题:Radionuclide labeling of vitamin B12 and coenzymes thereof
文献作者:Collins,D.A.; Hogenkamp,H.P.C.(Mayo Foundation for Medical Education and Research; University of Minnesota)
参考来源:WO 9718231
📄 详细内容
合成路线:Adenosylcobalamin-b-monocarboxylic acid (I) was coupled to 1,4-butanediamine (II) in the presence of EDC and HOBt to afford the N-(4-aminobutyl)amide (III).Subsequent acylation of amino amide (III) by diethylenetriaminopentaacetic dianhydride (IV) gave rise to the title compound.
参考文献标题:Transcobalamin II receptor imaging via radiolabeled diethylene-triaminepentaacetate cobalamin analogs
文献作者:Collins,D.A.; Hogenkamp,H.P.C.
参考来源:J Nucl Med 1997,38(5),717