BIA-3-335
Chemical Name: 1-(3,4-Dihydroxy-5-nitrophenyl)-3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-one dihydrochloride
CAS No. 359783-06-5
项目整合开发状态: Preclinical
项目研究机构: Bial (Originator), Portela (Originator)
合成路线:The title compound is prepared by condensation between 2-chloro-1-(3,4-dihydroxy-5-nitrophenyl)ethanone (I) and 1-(3-trifluoromethylphenyl)piperazine (II) in DMF,followed by conversion to the corresponding dihydrochloride salt.
📌 参考资料/链接:
参考文献标题:Novel substd.nitrocatechols,their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compsns.containing them
文献作者:Learmonth,D.A.; Soares Da Silva,P.M.V.A.(Portela & Ca.,SA)
参考来源:EP 1167342; WO 0198251