项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

SM-295072

Chemical Name: 6-Amino-9-benzyl-2-(2-hydroxyethylsulfanyl)-9H-purin-8-ol; 9-Benzyl-8-hydroxy-2-(2-hydroxyethylsulfanyl)adenine
CAS No. 226907-03-5 (tautomer)
项目整合开发状态: Preclinical
项目研究机构: Jap...
参考文献标题:Novel heterocyclic cpds.
文献作者:Kawakami,H.; Ogino,T.; Kurimoto,A.(Japan Energy Corp.; Sumitomo Pharmaceuticals Co.,Ltd.)
参考来源:EP 1035123; US 6329381; WO 9928321

C-1330-7, CT-50547

Chemical Name: N-(6-Ethoxybenzothiazol-2-yl)-2-(8-ethoxy-4-hydroxy-2,2-dioxo[1,2,4]thiadiazino[3,4-b]benzothiazol-3-yl)-2-oxoethane-1-sulfonamide
CAS No. 230962-91-1
项目整合开发状态: Preclinical
项目研...
参考文献标题:Platelet ADP receptor inhibitors
文献作者:Jantzen,H.-M.; Scarborough,R.M.; Conley,P.B.; Fretto,L.J.; Laibelman,A.M.(COR Therapeutics,Inc.)
参考来源:EP 1047699; JP 2002509152; WO 9936425

新产品编号:603251

Chemical Name: 1-Benzyl-3-phenyl-3,4-dihydroquinolin-2(1H)-one
CAS No. 231289-46-6
项目整合开发状态: Biological Testing
项目研究机构: Chonnam National University (Originator)
合成路线:Condensation of 2-nitr...
参考文献标题:Studies on the synthesis and in vitro antitumor activity of the isoquinolone derivatives
文献作者:Cho,W.-J.; Lee,J.Y.; Chung,B.-H.; Kim,T.S.; Choi,B.-G.; Cheon,S.H.
参考来源:Arch Pharmacal Res 1999,22(2),179

新产品编号:446633

Chemical Name: 2-Methyl-2(Z)-butenoic acid (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetoxy-4-[3-(4-aminophenyl)-2(E)-propenoyloxy]-3,3a-dihydroxy-7-(octanoyloxy)-2-oxo-3,6,9-trimethyl-2,3,3a,4,5,6,6a,7,8,9b-de...
参考文献标题:Tissue specific prodrug
文献作者:Christensen,S.B.; Issacs,J.T.; Denmeade,S.R.; Lilja,H.(Johns Hopkins University)
参考来源:WO 9852966

RPR-209685

Chemical Name: 4-[2-(5-Chlorothien-2-yl)vinylsulfonyl]-1-(1H-pyrrolo[3,2-c]pyridin-2-ylmethyl)piperazin-2-one
CAS No. 234100-28-8
项目整合开发状态: Preclinical
项目研究机构: Aventis Pharma (Originator)
...
参考文献标题:Substd.oxoazaheterocyclyl factor Xa inhibitors
文献作者:Hanney,B.A.; He,W.; Poli,G.B.; Spada,A.P.; Myers,M.R.; Burns,C.J.; Pauls,H.W.; Jiang,J.Z.; Condon,S.M.; Ewing,W.R.; Becker,M.R.; Li,A.; Choi-Sledeski,Y.M.; Lau,W.F.; Davis,R.S.(Aventis Pharmaceuticals,Inc.)
参考来源:EP 1051176; WO 9937304

RWJ-56110

Chemical Name: 4-Amino-N-benzyl-2(S)-[2(S)-[3-[1-(2,6-dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indol-6-yl]ureido]-3-(3,4-difluorophenyl)propionamido]butyramide
CAS No. 252889-88-6
项目整合开发状态: ...
参考文献标题:Design,synthesis,and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor
文献作者:Andrade-Gordon,P.; Maryanoff,B.E.; Derian,C.K.; Zhang,H.C.; Addo,M.F.; Darrow,A.L.; Eckardt,A.J.; Hoekstra,W.J.; McComsey,D.F.; Oksenberg,D.; Reynolds,E.E.; Santulli,R.J.; Scarborough,R.M.; Smith,C.E.; White,K.B.
参考来源:Proceedings of the National Academy of Sciences of the United States of America 1999,96(22),12257

NNC-21-0147

Chemical Name: 5'-Deoxy-2,5'-dichloro-N-[4-(phenylsulfanyl)-1-piperidinyl]adenosine
CAS No. 169190-51-6
项目整合开发状态: Preclinical
项目研究机构: Novo Nordisk (Originator)
合成路线:By chlorination of 2-ch...
参考文献标题:Chemical cpds.,their preparation and use
文献作者:Lau,J.; Knutsen,L.J.S.(Novo Nordisk A/S)
参考来源:EP 0719275; JP 1999511436; US 5589467; WO 9507921

M-55551

Chemical Name: 4-(6-Chloronaphthalen-2-ylsulfonyl)-6-oxo-1-[1-(4-pyridyl)piperidin-4-ylmethyl]piperazine-2(R)-carboxylic acid
CAS No. 229646-76-8, 229647-04-5 (methanesulfonate), 229646-52-0 (undef...
参考文献标题:Aromatic cpds.having cyclic amino or salts thereof
文献作者:Miyazaki,Y.; Mukaihira,T.; Nishida,H.; Hosaka,Y.; Matsusue,T.(Mochida Pharmaceutical Co.,Ltd.)
参考来源:EP 1048652; WO 9933805

M-55190

Chemical Name: 4-(6-Chloronaphthalen-2-ylsulfonyl)-6-oxo-1-[1-(pyridin-4-yl)piperidin-4-ylmethyl]piperazine-2(R)-carboxylic acid ethyl ester methanesulfonate
CAS No. 229647-00-1, 229647-01-2 ((S)-i...
参考文献标题:Aromatic cpds.having cyclic amino or salts thereof
文献作者:Miyazaki,Y.; Mukaihira,T.; Nishida,H.; Hosaka,Y.; Matsusue,T.(Mochida Pharmaceutical Co.,Ltd.)
参考来源:EP 1048652; WO 9933805

BMS-282594

Chemical Name: 4-[8-(3-Hydroxyphenyl)-5,5-dimethyl-5,6-dihydro-2-anthracenyl]benzoic acid
CAS No. 215176-49-1
项目整合开发状态: Biological Testing
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Co...
参考文献标题:Retinoid-like cpds.
文献作者:Starrett,J.E.Jr.; Tramposch,K.M.; Martel,A.; Nair,X.; Zusi,F.C.; Reczek,P.R.; Marinier,A.; Ericsson,A.(Bristol-Myers Squibb Co.)
参考来源:WO 9849136