C-1330-7, CT-50547
Chemical Name: N-(6-Ethoxybenzothiazol-2-yl)-2-(8-ethoxy-4-hydroxy-2,2-dioxo[1,2,4]thiadiazino[3,4-b]benzothiazol-3-yl)-2-oxoethane-1-sulfonamide
CAS No. 230962-91-1
项目整合开发状态: Preclinical
项目研究机构: Millennium (Originator)
合成路线:The title compound was obtained in a one-step procedure from 6-ethoxy-2-aminobenzothiazole (I) and chlorosulfonylacetyl chloride (II) in the presence of triethylamine.The initially formed sulfonamido acid chloride (III) cyclized to the benzothiazolo[2,3-c]thiadiazine ring system (IV),which subsequently underwent further acylation with another molecule of acid chloride (III) to furnish the title compound.
📌 参考资料/链接：
参考文献标题:Platelet ADP receptor inhibitors
文献作者:Jantzen,H.-M.; Scarborough,R.M.; Conley,P.B.; Fretto,L.J.; Laibelman,A.M.(COR Therapeutics,Inc.)
参考来源:EP 1047699; JP 2002509152; WO 9936425
📄 详细内容
合成路线:The title compound was obtained in a one-step procedure from 6-ethoxy-2-aminobenzothiazole (I) and chlorosulfonylacetyl chloride (II) in the presence of triethylamine.The initially formed sulfonamido acid chloride (III) cyclized to the benzothiazolo[2,3-c]thiadiazine ring system (IV),which subsequently underwent further acylation with another molecule of acid chloride (III) to furnish the title compound.
参考文献标题:Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y12)
文献作者:Scarborough,R.M.; Laibelman,A.M.; Clizbe,L.A.; Fretto,L.J.; Conley,P.B.; Reynolds,E.E.; Sedlock,D.M.; Jantzen,H.
参考来源:Bioorg Med Chem Lett 2001,11(14),1805