SM-295072

Chemical Name: 6-Amino-9-benzyl-2-(2-hydroxyethylsulfanyl)-9H-purin-8-ol; 9-Benzyl-8-hydroxy-2-(2-hydroxyethylsulfanyl)adenine
CAS No. 226907-03-5 (tautomer)
项目整合开发状态: Preclinical
项目研究机构: Japan Energy (Originator), Sumitomo Pharmaceuticals (Originator)
合成路线:Condensation between aminomalononitrile (I) and benzyl isocyanate (II) produces imidazole (III).This is then cyclized with benzoyl isothiocyanate (IV) in the presence of NaOH to furnish the mercaptopurine derivative (V).Finally,alkylation of thiol (V) with 2-bromoethanol (VI) gives rise to the target hydroxyethyl sulfide.