新产品编号:603251

Chemical Name: 1-Benzyl-3-phenyl-3,4-dihydroquinolin-2(1H)-one
CAS No. 231289-46-6
项目整合开发状态: Biological Testing
项目研究机构: Chonnam National University (Originator)
合成路线:Condensation of 2-nitrobenzaldehyde (I) with methyl phenylacetate (II) in the presence of lithium diisopropylamide in cold THF provided hydroxyester (III).Reduction of the nitro group of (III) with concomitant cyclization by hydrogenation over Pd/C in EtOAc produced the dihydroquinolinone (IV).Further hydrogenolysis of the hydroxyl group of (IV) over Pd/C in AcOH gave (V),which was finally alkylated with benzyl bromide and NaH to yield the N-benzylquinolinone.