项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:604833

Chemical Name: 1-[2-[3,4-Bis(benzyloxy)-5-oxofuran-2-ylidene]ethyl]-5-trifluoromethyl-1,3-dihydropyrimidine-2,4-dione
CAS No. 231619-86-6
项目整合开发状态: Biological Testing
项目研究机构: Rega Institute f...
参考文献标题:Novel pyrimidine and purine derivatives of L-ascorbic acid: Synthesis and biological evaluation
文献作者:Raic-Malic,S.; Hergold-Brundic,A.; Nagl,A.; Grdisa,M.; Pavelic,K.; De Clercq,E.; Mintas,M.
参考来源:J Med Chem 1999,42(14),2673

新产品编号:95429

Chemical Name: 3-[4-(5-Methyl-2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)piperidin-1-ylmethyl]benzonitrile
CAS No. 164393-22-0
项目整合开发状态: Preclinical
项目研究机构: Merck Sharp & Dohme (Originator)<...
参考文献标题:Imidazolone and oxazolone derivs.as dopamine antagonists
文献作者:Carling,W.R.; Moore,K.W.(Merck Sharp & Dohme Ltd.)
参考来源:EP 0719264; JP 1997504272; US 5698573; WO 9507904

新产品编号:524151

Chemical Name: N-[2-[N-[5-Methoxy-1,2,3,4-tetrahydronaphthalen-2(R)-yl]-N-propylamino]ethyl]benzamide hydrochloride
CAS No. 220772-98-5 (racemate), 220772-95-2 (racemic free base)
项目整合开发状态: Prec...
参考文献标题:Synthesis and pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT
文献作者:Homan,E.J.; Copinga,S.; Unelius,L.; Jackson,D.M.; Wikstrom,H.V.; Grol,C.J.
参考来源:Bioorg Med Chem 1999,7(7),1263

SW-68210

Chemical Name: N-[1-[2-(Diethylamino)ethylamino]-10-oxo-10H-dibenzo[b,e]thiopyran-4-ylmethyl]carbamic acid methyl ester
CAS No. 155990-11-7
项目整合开发状态: Biological Testing
项目研究机构: Sanofi-Aventis...
参考文献标题:Lyophilized thioxanthenone antitumor agents
文献作者:Brown,S.; Sandhu,G.S.(Sanofi-Synthabo)
参考来源:WO 9710809

BNP-1100

Chemical Name: 4(S)-Ethyl-4-hydroxy-11-(methylsulfanyl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 7-(Methylsulfanyl)camptothecin
CAS No. 203923-75-5
项目整合开发状态: Biological...
参考文献标题:Highly lipophilic camptothecin derivs.
文献作者:Seetharamulu,P.; Reddy,D.G.; Petluru,P.; Haridas,K.; Yao,S.; Hausheer,F.H.; Murali,D.(BioNumerik Pharmaceuticals,Inc.)
参考来源:WO 9807727

Elaidic acid-Cytarabine, P-4055

Chemical Name: 5'-O-[9(E)-Octadecenoyl]-1-beta-D-arabinofuranosylcytosine; 4-Amino-1-[5-O-[9(E)-octadecenoyl]-beta-D-arabinofuranosyl]-2(1H)-pyrimidinone
CAS No. 188181-42-2
项目整合开发状态: Preclinica...
参考文献标题:Improved therapeutic agents
文献作者:Borretzen,B.; Myhren,F.; Dalen,A.; Stokke,K.T.(Norsk Hydro AS)
参考来源:WO 9705154

SS-750

Chemical Name: (-)-2(R)-(2,4-Difluorophenyl)-1-(ethylsulfonyl)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)propan-2-ol
CAS No. 229153-17-7, 229153-16-6 ((+)-(S)-isomer), 229153-10-0 (racemate)
项目整合开发状...
参考文献标题:Triazole deriv.or salt thereof,preparation process thereof as well as pharmaceutical containing said cpd.
文献作者:Matsumoto,M.; Kaneko,Y.; Maebashi,K.; Takeda,S.; Sato,S.; Tokizawa,M.; Ishida,K.; Eto,H.; Asaoka,T.(SSP Co.,Ltd.)
参考来源:CA 2256060; EP 0927719; JP 1999240871; US 6083968

NPS-1392

Chemical Name: (-)-3,3-Bis(3-fluorophenyl)-2(R)-methylpropan-1-amine hydrochloride
CAS No. 200427-53-8, 170018-66-3 (free base), 186495-92-1 (monoHI)
项目整合开发状态: Preclinical
项目研究机构: NPS Pharmac...
参考文献标题:Cpds.active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
文献作者:Moe,S.T.; Mueller,A.L.(NPS Pharmaceuticals,Inc.)
参考来源:WO 9856752

新产品编号:150799

Chemical Name: 5-(4-Aminophenyl)-8(R)-methyl-7-(2-pyridinyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h]-2,3-benzodiazepine
CAS No. 178751-16-1
项目整合开发状态: Preclinical
项目研究机构: Lilly (Originator)
合成路线:...
参考文献标题:Physical form of dihydro-2,3-benzodiazepine deriv.
文献作者:Anderson,B.A.; Hansen,M.M.; Vicenzi,J.T.; Varie,D.L.; Zmijewski,M.J.Jr.; Harkness,A.R.(Eli Lilly and Company)
参考来源:EP 0699676; JP 1996081468; JP 1996081469; JP 1996092255; JP 1998505066; US 5795886

新产品编号:631727

Chemical Name: N-[3-[N-(4-Cyanobenzyl)-N-[1-(4-cyanobenzyl)-1H-imidazol-5-ylmethyl]aminomethyl]benzoyl]-L-methionine
CAS No. 245126-51-6
项目整合开发状态: Biological Testing
项目研究机构: Merck & Co. (Orig...
参考文献标题:Non-thiol 3-aminomethylbenzamide inhibitor of farnesyl-protein transferase
文献作者:Ciccarone,T.M.; MacTough,S.C.; Williams,T.M.; Dinsmore,C.J.; O'Neill,T.J.; Shah,D.; Culberson,J.C.; Koblan,K.S.; Kohl,N.E.; Gibbs,J.B.; Oliff,A.I.; Graham,S.L.; Hartman,G.D.
参考来源:Bioorg Med Chem Lett 1999,9(14),1991