新产品编号:604833

Chemical Name: 1-[2-[3,4-Bis(benzyloxy)-5-oxofuran-2-ylidene]ethyl]-5-trifluoromethyl-1,3-dihydropyrimidine-2,4-dione
CAS No. 231619-86-6
项目整合开发状态: Biological Testing
项目研究机构: Rega Institute for Medical Research (Originator), Rudjer Boskovic Institute (Originator), University of Zagreb (Originator)
合成路线:The title pyrimidine derivative was synthesized by silylation of 5-(trifluoromethyl)uracil (I) with hexamethyldisilazane,followed by condensation with 5,6-diacetyl-2,3-dibenzyl-L-ascorbic acid (II) in the presence of trimethylsilyl triflate.
📌 参考资料/链接:
参考文献标题:Novel pyrimidine and purine derivatives of L-ascorbic acid: Synthesis and biological evaluation
文献作者:Raic-Malic,S.; Hergold-Brundic,A.; Nagl,A.; Grdisa,M.; Pavelic,K.; De Clercq,E.; Mintas,M.
参考来源:J Med Chem 1999,42(14),2673