项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

新产品编号:976603

1,2-苯二醇,4-[2-(丁基丙基氨基)乙基]- Chemical Name: 4-(2-N-n-Propyl-N-n-butylaminoethyl)-1,2-benzenediol hydrochloride; N-n-Propyl-N-n-butyl-beta-(3,4-dihydroxyphenyl)ethylamine hydrochloride; N-n-Propyl-N-n-bu...
参考文献标题:Propylbutyldopamine hydrochloride
文献作者:Ginos,J.Z.
参考来源:Drugs Fut 1986,11(3),191

trans-ISA-247, ISA-247, R-1524, ISAtx-247

1,4,7,10,13,16,19,22,25,28,31-十一aza环三三康坦,环肽衍生物 Chemical Name: Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-[3(R)-hydroxy-N,4(R)-dimethyl-L-2-amino-6(E),8-nonadienoyl]-...
参考文献标题:Novel cyclosporin analog formulations
文献作者:Yatscoff,R.W.; Foster,R.T.; Naicker,S.A.(Isotechnika Inc.)
参考来源:US 2003171264; WO 0332949

Ametantrone acetate, NSC-287513(diacetate), NSC-196473(free base), CI-881

1,4-二((2-((2-羟基乙基)氨基)乙基)氨基)蒽醌二乙酸盐阿美蒽醌Chemical Name: 1,4-Bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone acetate (salt); 1,4-Bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione ac...
参考文献标题:Ametantrone acetate
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Hillier,K.
参考来源:Drugs Fut 1982,7(5),303

INO-2628(free base), INO-2628CZ

1,4-双(环丙基甲基)哌嗪 Chemical Name: 1,4-Bis(cyclopropylmethyl)piperazine dihydrochloride; N,N-Dicyclopropylmethylpiperazine dihydrochloride
CAS No. 82909-97-5, 82909-96-4 (free base)
项目整合开发状态: Phase ...
参考文献标题:Cyclopropylmethyl piperazines,the process for preparing the same and their use in therapeutics
文献作者:Robba,M.F.; Aurousseau,M.E.(Laboratoire Innothera SA)
参考来源:CA 1171085; EP 81401516; FR 8021527; JP 163681; US 4474783

Omoconazole nitrate, HOC-155, Sgd-12878(free base), CM-8282(free base), Anfongan, Omotrex, Fangorex, Afonga, Fungisan, Fongamil, Fongarex

1-[(1Z)-1-[2-(4-氯苯氧基)乙氧基]-1-(2,4-二氯苯基)-1-丙烯-2-基]-1H-咪唑 Chemical Name: (Z)-1-[2,4-Dichloro-beta-[2-(p-chlorophenoxy)ethoxy]-alpha-methylstyryl]imidazole nitrate; (Z)-1-(2,4-dichlorophenyl)-1-[2-(4-chl...
参考文献标题:Omoconazole nitrate
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1998,13(7),624

PD-174494, Co-101244

1-[2-(4-羟基苯氧基)乙基]-4-(4-甲基苄基)-4-哌啶醇盐酸盐(1:1) Chemical Name: 1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidin-4-ol hydrochloride
CAS No. 193356-17-1, 193359-26-1 (free base), 222421-41-2 (he...
参考文献标题:Synthesis and SAR of 4-benzyl-4-hydroxy-N-(hydroxy
文献作者:Zhou,Z.-L.; et al.
参考来源:216th ACS Natl Meet (Aug.23-27,Boston) 1998,Abst MEDI 114

Y-700

1-[3-氰基-4-(2,2-二甲基丙氧基)苯基]-1H-吡唑-4-羧酸Chemical Name: 1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid
CAS No. 206884-98-2
项目整合开发状态: Phase I
项目研究机构: Mitsubishi Pharma (Or...
参考文献标题:1-Phenylpyrazole cpds.and medicinal application thereof
文献作者:Ishibuchi,S.; Morimoto,H.; Inoue,H.; Naka,Y.; Fukunari,A.(Welfide Corporation)
参考来源:EP 0936217; US 6015829; WO 9818765

Otenzepad, AF-DX 116, AF-DX 116 BS

11-((2-((二乙氨基)甲基)-1-哌啶基)乙酰基)-5,11-二氢-(6H)-吡啶并[2.3-b][1.4]苯并二氮杂-6-酮 Chemical Name: (?-11-[[2-[[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
CAS ...
参考文献标题:Condensed diazepinones,process for their preparation and medicines containing them
文献作者:Schmidt,G.; Hammer,R.; Giachetti,A.; Engel,W.; Trummlitz,G.; Eberlein,W.; Mihm,G.(Dr.Karl Thomae GmbH)
参考来源:AU 8539815; EP 0156191; ES 8607282; ES 8702908; JP 1985215683; US 4550107

Sumanirole maleate, U-95666(free base), U-95666E, PNU-95666E, PNU-95666A, U-95666A

1-CBZ-3-哌啶甲醛(R)-5-(甲基氨基)-5,6-二氢-1H-咪唑并[4,5,1-ij]喹啉-2(4h)-酮Chemical Name: 5(R)-(Methylamino)-2,4,5,6-tetrahydro-1H-imidazo[4,5,1-ij]quinolin-2-one maleate
CAS No. 179386-44-8, 194919-11-4 (error), ...
参考文献标题:Synthesis of the selective D2 receptor agonist PNU-95666E from D-phenylalanine using a sequential oxidative cyclization strategy
文献作者:Romero,A.G.; et al.
参考来源:J Org Chem 1997,62(19),6582

CI-943

1H-伊咪唑[1,2-c]吡嘧唑[3,4-e]嘧啶,8-乙基-7,8-二氢-1,3,5-三甲基- Chemical Name: 8-Ethyl-1,3,5-trimethyl-7,8-dihydro-1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidine
CAS No. 111770-15-1 (racemate), 89239-35-0 (undefined...
参考文献标题:The potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines
文献作者:Wise,L.D.; Heffner,T.G.
参考来源:Drugs Fut 1989,14(11),1073