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Ametantrone acetate, NSC-287513(diacetate), NSC-196473(free base), CI-881

1,4-二((2-((2-羟基乙基)氨基)乙基)氨基)蒽醌二乙酸盐 阿美蒽醌Chemical Name: 1,4-Bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone acetate (salt); 1,4-Bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione acetate (salt)
CAS No. 73334-06-2, 70711-40-9 (diacetate), 64862-96-0 (free base)
项目整合开发状态: Phase I
项目研究机构: Pfizer (Originator)
合成路线:By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol,followed by oxidation with air and treatment with acetic acid.
📌 参考资料/链接:
参考文献标题:Ametantrone acetate
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Hillier,K.
参考来源:Drugs Fut 1982,7(5),303

📄 详细内容


合成路线:By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol,followed by oxidation with air and treatment with acetic acid.

合成路线:By condensation of 1,4,5,8-tetrahydroxyanthraquinone (I) with ethylenediamine (II) in hot tetramethylethylenediamine.

参考文献标题:Antitumor agents.1.1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones
文献作者:Murdock,K.C.; Child,R.G.; Fabio,P.F.; Angier,R.B.; Wallace,R.E.; Durr,F.E.; Citarella,R.V.
参考来源:J Med Chem 1979,22(9),1024


合成路线:By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol,followed by oxidation with air and treatment with acetic acid.

参考文献标题:
文献作者:Hoare,R.C.
参考来源:US 4051155


合成路线:By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol,followed by oxidation with air and treatment with acetic acid.

参考文献标题:
文献作者:Hoare,R.C.
参考来源:FR 2399244


合成路线:By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol,followed by oxidation with air and treatment with acetic acid.
参考文献标题:
文献作者:Hoare,R.C.
参考来源:DE 2734907


产品链接: CAS No.70711-40-9››

产品链接: CAS No.64862-96-0››