项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Tubulozole hydrochloride, R-46846

盐酸九布洛唑-C Chemical Name: Ethyl (?-cis-[4-[[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl]thio]phenyl]carbamate monohydrochloride; Ethyl (?-cis-p-[[[2-(2,4-dichlorophenyl...
参考文献标题:Tubulozole Hydrochloride
文献作者:Van Ginckel,R.; Geuens,G.; Heeres,J.
参考来源:Drugs Fut 1984,9(12),911

Oximonam sodium, SQ-82629, SQ-82291

肟莫南 Chemical Name: [[(2S,3S)-3-[(2-Amino-4-thiazolyl)glyoxylamido]-2-methyl-4-oxo-1-azetidinyl]oxy]acetic acid 3(2)-(Z)-(O)-methyloxime sodium salt; [[4(S)-Methyl-3(S)-[(2-amino-4-thiazolyl)-2(Z)-(m...
参考文献标题:beta-Lactam derivs.
文献作者:Breuer,H.; Straub,H.; Treuner,U.D.(Von Heyden)
参考来源:DE 3328047; GB 2125794

Sulbactam sodium, CP-458992, Combactam

舒巴坦酸 Chemical Name: (2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide sodium salt
CAS No. 69388-34-7, 68373-14-8 (free acid)
项目整合开发状态: Launched-1986 参考文献标题:Therapeutic agents
文献作者:Wayne,E.B.(Pfizer Inc.)
参考来源:BE 0867859; FR 2393804; GB 2000138; NL 7806126

Napitane mesilate, ABT-200, A-75200

萘吡坦 Chemical Name: (?-1-[5,6-(Methylenedioxy)-1,2,3,4-tetrahydronaphth-1(R*)-ylmethyl]-3(R*)-phenylpyrrolidine methanesulfonate; (?-3(R*)-Phenyl-1-[6,7,8,9-tetrahydronaphtho[1,2-d]-1,3-dioxol-6(R*)-...
参考文献标题:A scalable process for the novel antidepressant ABT-200
文献作者:Deshpande,M.N.; et al.
参考来源:Org Process Res Dev 1998,2(6),351

Benidipine hydrochloride, KW-3049, Coniel R, Coniel

贝尼地平 Chemical Name: (?-(R*)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid methyl (R*)-1-benzylpiperidin-3-yl diester hydrochloride
CAS No. 85387-35-5, 105979-17-7 (free...
参考文献标题:1,4-Dihyropiridine derivatives
文献作者:Muto,K.; Watanabe,M.; Hatta,T.; Sugaya,T.; Takemoto,Y.; Nakamizo,N.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:EP 0063365; JP 57171968; US 4448964

Iofetamine hydrochloride I-123, Ro-23-1507/001, M-123, IMP, Spectamine A

(+-)-4-(碘-123I)-alpha-甲基-N-(1-甲基乙基)-苯乙胺 Chemical Name: (?-N-Isopropyl-p-[(123)I]-iodoamphetamine hydrochloride; (?-4-(Iodo-(123)I)-alpha-methyl-N-(1-methylethyl)benzeneethanamine hydrochloride; (?-p-...
参考文献标题:Iofetamine (123I) hydrochloride
文献作者:Baldwin,R.M.
参考来源:Drugs Fut 1986,11(8),652

Rogletimide, Pyridoglutethimide, PG

(+/-) 3-乙基-3-(4-吡啶)-2,6-哌啶二酮 Chemical Name: (?-3-Ethyl-3-(4-pyridyl)piperidine-2,6-dione; (?-2-Ethyl-2-(4-pyridyl)glutarimide
CAS No. 121840-95-7, 92788-10-8 (undefined stereoch.)
项目整合开发状态: Pha...
参考文献标题:2,6-Dioxopiperidine derivs.,their preparation and pharmaceutical compsns.containing them
文献作者:Foster,A.B.; Jarman,M.; Taylor,G.N.; Kwan,C.-S.(Institute of Cancer Research)
参考来源:EP 0147121; GB 2151226; JP 1986500613; US 5071857; WO 8502618

Tazifylline hydrochloride, RS-49014

(±)-他齐茶碱 Chemical Name: 7-[2-Hydroxy-3-[4-[3-(phenylthio)propyl]-1-piperazinyl]propyl]theophylline dihydrochloride; 3,7-Dihydro-7-[2-hydroxy-3-[4-[3-(phenylthio)propyl]-1-piperazinyl]propyl]-1,3-dime...
参考文献标题:Piperazine derivatives of theophylline
文献作者:Favier,C.; Pinhas,H.; Beranger,S.; Pascal,J.-C.(Roche Bioscience)
参考来源:EP 0033674; GB 2069487; JP 56120683; US 4374835

Mitemcinal fumarate, GM-611

(1S,2R,3S,4S,5R,8R,9R,11S)-8-乙基-4-[(2R,4R,5S,6S)-5-羟基-4-甲氧基-4,6-二甲基四氢吡喃-2-基]氧基-2-[(2S,3R,4S,6R)-3-羟基-6-甲基-4-(甲基-丙-2-基氨基)四氢吡喃-2-基]氧基-9-甲氧基-1,3,5,9,11,13-六甲基-7,15-二氧杂双环[10.2.1]十五碳-12-烯-6,10-二酮 Chemical...
参考文献标题:Erythromycin derivs
文献作者:Koga,H.; Sato,T.; Takanashi,H.(Chugai Pharmaceutical Co.Ltd.)
参考来源:EP 0643068; JP 1994056873; US 5658888; WO 9324509

Canfosfamide hydrochloride, TLK-286, TER-286, Telcyta

(2R)-L-gamma-谷氨酰-3-((2-((二(二(2-氯乙基)氨基)亚膦酰)氧基)乙基)磺酰基)-L-丙氨酰-2-苯基甘氨酸 Chemical Name: 2(R)-[2-[4(S)-Amino-4-carboxybutyramido]-3-[2(R)-[bis[N,N-bis(2-chloroethyl)amino]phosphoryloxy]ethylsulfonyl]propion...
参考文献标题:Glutathione S-transferase-activated cpds.
文献作者:Kauvar,L.; Lyttle,M.H.; Satyam,A.(Telik,Inc.)
参考来源:WO 9509866