网站主页>>>
项目整合精选>>>
项目整合精选>>>Omoconazole nitrate, HOC-155, Sgd-12878(free base), CM-8282(free base), Anfongan, Omotrex, Fangorex, Afonga, Fungisan, Fongamil, Fongarex
Omoconazole nitrate, HOC-155, Sgd-12878(free base), CM-8282(free base), Anfongan, Omotrex, Fangorex, Afonga, Fungisan, Fongamil, Fongarex
1-[(1Z)-1-[2-(4-氯苯氧基)乙氧基]-1-(2,4-二氯苯基)-1-丙烯-2-基]-1H-咪唑 Chemical Name: (Z)-1-[2,4-Dichloro-beta-[2-(p-chlorophenoxy)ethoxy]-alpha-methylstyryl]imidazole nitrate; (Z)-1-(2,4-dichlorophenyl)-1-[2-(4-chlorophenoxy)ethoxy]-2-(1-imidazolyl)propene nitrate
CAS No. 111122-38-4, 74512-12-2 (free base, (E)-isomer), 83621-06-1 (mononitrate)
项目整合开发状态: Launched-1991
项目研究机构: Sanofi-Aventis (Originator), Siegfried (Originator), Galderma (Licensee), Hisamitsu (Licensee)
合成路线:By condensation of 2,4-dichloro-alpha-(1-imidazolyl)propiophenone (I) with 2-(4-chlorophenoxy)ethyl bromide (II) by means of NaH in HMPT (hexamethylphosphotriamide) or by means of NaOH tetrabutylammonium hydroxide in toluene water,and separation of the (Z)- and (E)-isomers by crystallization of the corresponding nitrates.
📌 参考资料/链接：
参考文献标题:Omoconazole nitrate
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1998,13(7),624
📄 详细内容
合成路线:By condensation of 2,4-dichloro-alpha-(1-imidazolyl)propiophenone (I) with 2-(4-chlorophenoxy)ethyl bromide (II) by means of NaH in HMPT (hexamethylphosphotriamide) or by means of NaOH tetrabutylammonium hydroxide in toluene water,and separation of the (Z)- and (E)-isomers by crystallization of the corresponding nitrates.
参考文献标题:Antimycotic imidazolyl-alkenes: Synthesis and X-ray crystal structure of omoconazole
文献作者:Thiele,K.; Zirngibl,L.; Pfenninger,M.H.; et al.
参考来源:Helv Chim Acta 1987,70(2),441-444
产品链接: CAS No.74512-12-2››