项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

LY-341122

Chemical Name: 2,6-Di-tert-butyl-4-[4-[2-[4-(N-ethyl-N-methylaminomethyl)phenoxy]ethyl]oxazol-2-yl]phenol
CAS No. 206121-95-1, 206121-94-0 (monoHCl)
项目整合开发状态: Preclinical
项目研究机构: Lilly (Origi...
参考文献标题:Novel cpds.useful as neuro-protective agents
文献作者:Heinz,L.J.; Panetta,J.A.; Phillips,M.L.; Shadle,J.K.(Eli Lilly and Company)
参考来源:EP 0971709; WO 9815274

KF-26777

Chemical Name: 2-(4-Bromophenyl)-4-propyl-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]purin-5-one dihydrochloride
CAS No. 206129-88-6
项目整合开发状态: Biological Testing
项目研究机构: Kyowa Hakko (Originator)
...
参考文献标题:Fused purine derivs.
文献作者:Tsumuki,H.; Saki,M.; Nonaka,H.; Ichimura,M.; Shimada,J.; Suzuki,F.; Ichikawa,S.; Kosaka,N.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:EP 0884318; US 6306847; WO 9815555

新产品编号:196677

Chemical Name: N-[1(S)-[2,2-Dimethyl-1-(methylcarbamoyl)propyl]-2-(2-sulfanylacetyl)nonanamide
CAS No. 186603-94-1
项目整合开发状态: Preclinical
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:Tit...
参考文献标题:Novel inhibitors of collagenase-1 and stromelysin-I metalloproteases,pharmaceutical compsns.comprising same and methods of their use
文献作者:Campbell,D.A.; Patel,D.V.; Xiao,X.Y.(Affymax Technologies,NV)
参考来源:WO 9640204

新产品编号:14747

Chemical Name: 5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione
CAS No. 114590-95-3
项目整合开发状态: Biological Testing
项目研究机构: University of Nottingham (Originator)
合成路线:Addition of benzylmagnesium...
参考文献标题:Synthesis of grevillins and their biogenetic interrelationship with terphenylquinones,xylerythrins and pulvinic acids
文献作者:Pattenden,G.; et al.
参考来源:Tetrahedron Lett 1987,28(4),4749

新产品编号:340639

Chemical Name: (9aR,13aR)-N-[2(S)-Amino-1(S)-cyclohexyl]-15-oxo-9a,10,11,12,13,13a,14,15-octahydro-9H-benzo[e]quinoxalino[2,3-i]perimidine-8-carboxamide
CAS No. 204204-27-3
项目整合开发状态: Preclinical...
参考文献标题:Synthesis and biological activity of oxo-7H-benzo[
文献作者:Luthin,D.R.; Rabinovich,A.K.; Bhumralkar,D.R.; Youngblood,K.L.; Bychowski,R.A.; Dhanoa,D.S.; May,J.M.
参考来源:Bioorg Med Chem Lett 1999,9(5),765

cPr-PMEDAP

Chemical Name: 2-(2,6-Diamino-N6-cyclopropylpurine-9-yl)ethoxymethylphosphonic acid; N6-Cyclopropyl-2,6-diamino-9-(2-phosphonomethoxyethyl)purine
CAS No. 182798-83-0
项目整合开发状态: Preclinical
项目研...
参考文献标题:N6-Substd.nucleotide analogues and their use
文献作者:Holy,A.; De Clercq,E.D.A.(Institute of Organic Chemistry and Biochemistry; Stichting Rega Vzw)
参考来源:US 5977061; WO 9633200

新产品编号:315327

Chemical Name: exo-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2(Z),4(E)-pentadienamide
CAS No. 202213-90-9
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmi...
参考文献标题:Indole derivs.useful in the treatment of osteoporosis
文献作者:Farina,C.; Gagliardi,S.; Parini,C.; Pinza,M.; Nadler,G.M.M.G.; Morvan,M.J.-M.(SmithKline Beecham SpA)
参考来源:JP 1998512251; WO 9621644

L-739943

Chemical Name: 2-Amino-2-methyl-N-[1-[2'-(3-methylureidomethyl)biphenyl-4-ylmethyl]-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3(R)-yl]propionamide
CAS No. 197650-99-0
项目整合开发状态: Preclinical
项目研...
参考文献标题:A potent,orally bioavailable benzazepinone growth hormone secretagogue
文献作者:DeVita,R.J.; Bochis,R.; Frontier,A.J.; Kotliar,A.; Fisher,M.H.; Schoen,W.R.; Wyvratt,M.J.; Cheng,K.; Chan,W.W.-S.; Butler,B.; Jacks,T.M.; Hickey,G.J.; Schleim,K.D.; Leung,K.; Chen,Z.; Lee Chiu,S.-H.; Feeney,W.P.; Cunningham,P.K.; et al.
参考来源:J Med Chem 1998,41(10),1716

S-3483

Chemical Name: (1S,3R,4R,5R)-1-[2(S)-(4-Chlorophenyl)-1(R)-cyclopropylmethoxy]-3,4-dihydroxy-5-[3-(4-hydroxyphenyl)-2(E)-propenoyloxy]cyclohexane-1-carboxylic acid
CAS No. 160341-09-3
项目整合开发状态: ...
参考文献标题:Derivs.of substd.cyclohexane,their process of preparation and their application for the treatment of diseases
文献作者:Hemmerle,H.; Schindler,P.; Herling,A.(Aventis SA)
参考来源:EP 0587088; JP 1994211736; US 5463062

SA-9499

Chemical Name: S-(4-Cyclohexylbenzyl)-N-[2(S)-methyl-3-sulfanylpropionyl]-L-cysteine
CAS No. 204694-54-2
项目整合开发状态: Biological Testing
项目研究机构: Santen (Originator)
合成路线:The esterification of...
参考文献标题:Novel sulfur-containing amino acid derivs.
文献作者:Horiuchi,M.; Fujimura,K.; Suhara,H.(Santen Pharmaceutical Co.,Ltd.)
参考来源:EP 0947502; JP 1998130225; US 6046235; WO 9809943