KF-26777

Chemical Name: 2-(4-Bromophenyl)-4-propyl-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]purin-5-one dihydrochloride
CAS No. 206129-88-6
项目整合开发状态: Biological Testing
项目研究机构: Kyowa Hakko (Originator)
合成路线:The cyclization of 5,6-diamino-1-propylpyrimidine-2,4(1H,3H)-dione (I) with 4-bromobenzoic acid (II) by means of EDC and HOBT in DMF gives 8-(4-bromophenyl)-3-propylxanthine (III),which is treated with P2S5 in refluxing pyridine to yield the 6-thioxanthine (IV).The reaction of (IV) with Me-I and NaOH in ethanol affords the methylsulfanylpurin-2-one (V),which is treated with ethanolamine (VI) in DMSO at 150 C to provide the 2-hydroxyethylamino derivative (VII).Finally,this compound is cyclized by means of SOCl2 in refluxing chloroform to provide the target imidazopurine.