新产品编号:340639

Chemical Name: (9aR,13aR)-N-[2(S)-Amino-1(S)-cyclohexyl]-15-oxo-9a,10,11,12,13,13a,14,15-octahydro-9H-benzo[e]quinoxalino[2,3-i]perimidine-8-carboxamide
CAS No. 204204-27-3
项目整合开发状态: Preclinical
项目研究机构: Agouron (Originator)
合成路线:Treatment of 7-oxo-7H-benzo[e]perimidine-4-carboxylic acid (I) with carbonyldiimidazole produced the corresponding acyl imidazolide (II).Reaction of this intermediate with 1,2-cyclohexanediamine (III) in DMF at 50 C afforded a mixture of amide (IV) and the title hexacyclic compound (V),which were separated by means of preparative HPLC.Alternatively,imidazolide (II) was first coupled with one equivalent of diamine (III) in DMF at r.t.to give amide (IV),which was then converted into the title compound by treatment with an excess of diamine (III) at 50 C.