cPr-PMEDAP

Chemical Name: 2-(2,6-Diamino-N6-cyclopropylpurine-9-yl)ethoxymethylphosphonic acid; N6-Cyclopropyl-2,6-diamino-9-(2-phosphonomethoxyethyl)purine
CAS No. 182798-83-0
项目整合开发状态: Preclinical
项目研究机构: Inst. Organic Chemistry Biochemistry (Originator), Rega Institute for Medical Research (Originator), Gilead (Codevelopment)
合成路线:Alkylation of 2-amino-6-chloropurine (I) with tosylate (II) afforded the phosphonomethoxyethyl purine (III).Subsequent displacement of the chloro atom of (III) by cyclopropylamine (IV) furnished diaminopurine (V).The isopropyl protecting groups of (IV) were finally cleaved by treatment with bromotrimethylsilane.

合成路线:In an alternative method for preparing precursor (V),2-amino-6-chloropurine (I) was first treated with cyclopropylamine (IV) to give diaminopurine (VI),and then alkylated with tosylate (II).