项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:373861

Chemical Name: 5-(3-Amino-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)thiazol-2-amine
CAS No. 206649-03-8
项目整合开发状态: Preclinical
项目研究机构: Ajinomoto (Originator)
合成路线:Wittig reaction of phosph...
参考文献标题:Syntheses and antitumor activity of cis-restricted combretastatins: 5-Membered heterocyclic analogues
文献作者:Ohsumi,K.; Hatanaka,T.; Fujita,K.; Nakagawa,R.; Fukuda,Y.; Nihei,Y.; Suga,Y.; Morinaga,Y.; Akiyama,Y.; Tsuji,T.
参考来源:Bioorg Med Chem Lett 1998,8(22),3153

新产品编号:362787

Chemical Name: 5-(2-Naphthylsulfanylmethyl)furo[2,3-d]pyrimidine-2,4-diamine
CAS No. 205503-28-2
项目整合开发状态: Preclinical
项目研究机构: Duquesne University (Originator), Indiana University (Originator...
参考文献标题:Selective Pneumocystis carinii dihydrofolate reductase inhibitors: Design,synthesis,and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines
文献作者:Gangjee,A.; Guo,X.; Queener,S.F.; Cody,V.; Galitsky,N.; Luft,J.R.; Pangborn,W.
参考来源:J Med Chem 1998,41(8),1263

新产品编号:353295

Chemical Name: 2-(3-Chlorophenyl)-4-phenyl-6,7-dihydro-5H-pyrido[3,2-d][1]benzazepin-6-one
CAS No. 205048-68-6
项目整合开发状态: Preclinical
项目研究机构: Universit鋞 Hamburg (Originator)
合成路线:Benzazepin...
参考文献标题:d-Fused[1]benzazepines with selective in vitro antitumor activity: Synthesis and structure-activity relationships
文献作者:Kunick,C.; Link,A.
参考来源:J Med Chem 1998,41(8),1299

FR-194738

Chemical Name: (E)-N-(6,6-Dimethylhept-2-en-4-ynyl)-N-ethyl-N-[3-[2-methyl-2-(thien-3-ylmethoxy)propoxy]benzyl]amine hydrochloride
CAS No. 204067-52-7, 204067-45-8 (free base), 204067-51-6 (oxalate...
参考文献标题:Substd.amine derivs.
文献作者:Okumura,H.; Washizuka,K.; Fujii,N.; Takasugi,H.(Fujisawa Pharmaceutical Co.,Ltd.)
参考来源:JP 2000517314; WO 9808838

WP-652

Chemical Name: N,N'-(1,4-Phenylene)bis(methylene)bis(4'-amino-3'-deamino-4'-deoxy-3'-hydroxydaunomycin) dihydrochloride
CAS No. 192708-89-7
项目整合开发状态: Biological Testing
项目研究机构: M.D. Anderson ...
参考文献标题:Bis-anthracyclines with high activity against doxorubicin resistant tumors
文献作者:Priebe,W.; Chaires,J.B.; Przewloka,T.; Fokt,I.; Perez-Soler,R.
参考来源:EP 0971716; JP 2000506899; WO 9734612

VUF-5087

Chemical Name: 6-Chloro-4-oxo-2-[3-[2(E)-(2-quinolyl)vinyl]phenyl]-4H-1-benzopyran-8-carboxylic acid
CAS No. 205875-33-8
项目整合开发状态: Preclinical
项目研究机构: Vrije Universiteit (Originator)
合成路线:...
参考文献标题:Synthesis and structure - activity relationships of carboxylated chalcones: A novel series of CysLT1 (LTD4) receptor antagonists
文献作者:Zwaagstra,M.E.; Timmerman,H.; Tamura,M.; Tohma,T.; Wada,Y.; Onogi,K.; Zhang,M.Q.
参考来源:J Med Chem 1997,40(7),1075

BILS-45-BS

Chemical Name: N-[2-[4-(2-Amino-4-thiazolyl)phenylamino]-2-oxoethyl]-N-(benzyl)pyridine-4-carboxamide
CAS No. 193346-20-2
项目整合开发状态: Preclinical
项目研究机构: Boehringer Ingelheim (Originator)
合成...
参考文献标题:Phenyl thiazole derivs.with anti-herpes virus properties
文献作者:Hargrave,K.D.; Simoneau,B.; Faucher,A.-M.; Thavonekham,B.; Grygon,C.A.; Crute,J.J.(Boehringer Ingelheim (Canada) Ltd.; Boehringer Ingelheim Pharmaceuticals Inc.)
参考来源:EP 0871619; JP 2000502702; US 6057451; WO 9724343

CPFPX

Chemical Name: 8-Cyclopentyl-3-(3-fluoropropyl)-1-propyl-3,7-dihydro-1H-purine-2,6-dione; 8-Cyclopentyl-3-(2-fluoropropyl)-1-propylxanthine
CAS No. 200557-18-2
项目整合开发状态: Preclinical
项目研究机构: U...
参考文献标题:A1 adenosine receptor antagonists as ligands for positron emission tomography (PET) and single-photon emission tomography (SPET)
文献作者:Holschbach,M.H.; Fein,T.; Krummeich,C.; Lewis,R.G.; Wutz,W.; Schwabe,U.; Unterlugauer,D.; Olsson,R.A.
参考来源:J Med Chem 1998,41(4),555

新产品编号:203005

Chemical Name: (Z)-5-[4-[2-[N-(6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-ylmethyl)-N-methylamino]ethoxy]benzylidene]-2,4-thiazolidinedione
CAS No. 187340-71-2 (undefined isomer) 参考文献标题:Cpds.having antidiabetic,hypolipidemic,antihypertensive properties,process for their preparation and pharmaceutical compsns.containing them
文献作者:Casturi,S.R.; Lohray,V.B.; Kallam,A.R.; Pingali,H.; Ramanujam,R.; Alla,S.R.(Dr.Reddy's Research Foundation)
参考来源:US 5925656

MR-20492

Chemical Name: (Z)-6-(4-Chlorophenyl)-7-(pyridin-4-ylmethylene)-5,6,7,8-tetrahydroindolizin-8-one
CAS No. 209529-76-0
项目整合开发状态: Preclinical
项目研究机构: CNRS (Originator), Universit?de Caen (Origi...
参考文献标题:Design and synthesis of a new type of non steroidal human aromatase inhibitors
文献作者:Sonnet,P.; Guillon,J.; Enguehard,C.; Dallemagne,P.; Bureau,R.; Rault,S.; Auvray,P.; Moslemi,S.; Sourdiane,P.; Galopin,S.; Seralini,G.E.
参考来源:Bioorg Med Chem Lett 1998,8(9),1041