新产品编号:362787
Chemical Name: 5-(2-Naphthylsulfanylmethyl)furo[2,3-d]pyrimidine-2,4-diamine
CAS No. 205503-28-2
项目整合开发状态: Preclinical
项目研究机构: Duquesne University (Originator), Indiana University (Originator)
合成路线:2,6-Diamino-4-hydroxypyrimidine (I) was cyclized with 1,3-dichloroacetone (II) in DMF at room temperature,and the resulting unstable furopyrimidine (III) was rapidly purified by a short column of silica gel and stored at -20 C.Then,the nucleophilic displacement reaction of chloride (III) with 2-naphthalenethiol (IV) in the presence of potassium carbonate in DMSO yielded the desired thioether.
📌 参考资料/链接：
参考文献标题:Selective Pneumocystis carinii dihydrofolate reductase inhibitors: Design,synthesis,and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines
文献作者:Gangjee,A.; Guo,X.; Queener,S.F.; Cody,V.; Galitsky,N.; Luft,J.R.; Pangborn,W.
参考来源:J Med Chem 1998,41(8),1263