项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

NNC-22-0215

Chemical Name: (+)-7-Chloro-1-(5,6-dichloro-2,3-dihydrobenzofuran-7-yl)-8-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No. 172306-73-9
项目整合开发状态: Preclinical
项目研究机构: Novo Nordisk (...
参考文献标题:2,3,4,5-Tetrahydro-1H-3-benzazepines and pharmaceutically acceptable acid addition salts thereof
文献作者:Foged,C.; Hohlweg,R.; Nielsen,E.B.(Novo Nordisk A/S)
参考来源:EP 0628039; JP 1995504172; US 5470850; WO 9317012

FR-20950

Chemical Name: (1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[2(R)-[2-(3-methyl-3H-imidazol-1-iumyl)ethyl]pyrrolidin-4(S)-ylsulfanyl]-1-carbapen-2-em-3-carboxylic acid chloride
CAS No. 156443-34-4 参考文献标题:Substd.3-pyrrolidinylthio-carbapenems as antimicrobial agents
文献作者:Murata,M.; Tsutsumi,H.; Matsuda,K.; Hattori,K.; Nakajima,T.(Fujisawa Pharmaceutical Co.,Ltd.)
参考来源:EP 0636133; JP 1995505650; WO 9321186

SNK-882

Chemical Name: 2-(2-Oxopyrrolidin-1-yl)-N-(perhydropyrrolizin-7a-ylmethyl)acetamide hydrochloride
CAS No. 152221-12-0, 108005-79-4 (free base)
项目整合开发状态: Phase III
项目研究机构: Sanwa (Originator) 参考文献标题:2-Oxopyrrolidine pharmaceutical compounds,salts and the preparation thereof
文献作者:Kurono,M.; Hayashi,M.; Suzuki,T.; Miura,K.; Kumagai,Y.; Matsumoto,Y.; Miyano,S.; Sumoto,K.(Sanwa Kagaku Kenkyusho Co.,Ltd.)
参考来源:EP 0213713; JP 1987022785; US 4678801

Holmium-166-DOTMP , 166Ho-DOTMP, STR

Chemical Name: 1,1',1'',1'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetrakis(methylphosphonate)holmium-166Ho; Pentahydrogen [[[(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl-kappaN1,kappaN...
参考文献标题:Bone marrow suppressing agents
文献作者:Simon,J.; Garlich,J.R.; Wilson,D.A.; McMillan,K.(Marion Merrell Dow,Inc.)
参考来源:EP 0374501; JP 1990237936; US 4882142

S-16961-1, S-16961

Chemical Name: (R,S)-1,2-O-Bis(hexadecanoyl)-3-O-(3-pyridylcarbonyl)glycerol; (d,l)-1,2-O-Dipalmitoyl-3-O-nicotinoylglycerol
CAS No. 160555-46-4
项目整合开发状态: Phase I
项目研究机构: ADIR (Originator), S...
参考文献标题:Diacylglycerol nicotinates
文献作者:Cordi,A.; Lacoste,J.-M.; Duhault,J.; Espinal,J.; Boulanger,M.(ADIR et Cie.)
参考来源:EP 0574312; JP 1994056786; US 5385920

Dofequidar fumarate, MS-209

Chemical Name: 5-[3-[4-(2,2-Diphenylacetyl)piperazin-1-yl]-2-hydroxypropoxy]quinoline sesquifumarate; 1-[4-(2,2-Diphenylacetyl)piperazin-1-yl]-3-(quinoliln-5-yloxy)-2-propanol sesquifumarate; 1-(Diphe...
参考文献标题:Structure-activity relationship of newly synthesiz
文献作者:Suzuki,T.; Fukazawa,N.; San-nohe,K.; Sato,W.; Yano,O.; Tsuruo,T.
参考来源:J Med Chem 1997,40(13),2047

S-21407, EGIS-7229(fumarate salt), GYKI-16306

Chemical Name: 5-Chloro-4-[3-[N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamino]propylamino]pyridazin-3(2H)-one
CAS No. 190333-92-7 (fumarate salt(1:1))
项目整合开发状态: Preclinical
项目研究机构: Egis (Origi...
参考文献标题:A new synthesis of EGIS-7229,a potent antiarrhythmic drug-candidate
文献作者:K髏ay-Nagy,P.; et al.
参考来源:15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998,Edinburgh) 1998,Abst P.151

R-91650

Chemical Name: 8-(Difluoromethoxy)-1-ethyl-6-fluoro-4-oxo-7-[4-(2-pyrimidinyl)piperazin-1-yl]-1,4-dihydroquinoline-3-carboxylic acid
CAS No. 153468-37-2
项目整合开发状态: Biological Testing
项目研究机构: S...
参考文献标题:Aminoquinolone derivs.as anti-HIV agents
文献作者:Kimura,T.; Katsube,T.(Ube Industries,Ltd.)
参考来源:EP 0572259; JP 1994116241; US 5519016; US 5688791

新产品编号:65371

Chemical Name: Sulfamic acid 5,6,7,8-tetrahydro-2-naphthyl ester
CAS No. 154532-55-5
项目整合开发状态: Preclinical
项目研究机构: University of Bath (Originator)
合成路线:By esterification of 5,6,7,8-tetrahy...
参考文献标题:Phosphonates and thiophosphonates as sulfate surrogates: Synthesis of estrone 3-methylthiophosphonate a potent inhibitor of estrone sulfatase
文献作者:Reed,M.J.; Potter,B.V.L.; Purohit,A.; Howarth,N.M.; Cooper,G.; Duncan,L.J.
参考来源:Bioorg Med Chem Lett 1993,3(2),313-318

SU-740(non-complexed), SU-840

Chemical Name: 4-tert-Butyl-2'-(carboxymethoxy)-4'-(3-methyl-2-butenyloxy)chalcone beta-cyclodextrin complex; (E)-2-[2-(4-tert-Butylcinnamoyl)-5-(3-methyl-2-butenyloxy)phenoxy]acetic acid beta-cyclode...
参考文献标题:Chalcone derivs
文献作者:Yokomori,S.; Saijo,K.; Matsunaga,T.; Nakashima,Y.; Hatayama,K.(Taisho Pharmaceutical Co.,Ltd.)
参考来源:EP 0412803; JP 1991163042