Holmium-166-DOTMP , 166Ho-DOTMP, STR

Chemical Name: 1,1',1'',1'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetrakis(methylphosphonate)holmium-166Ho; Pentahydrogen [[[(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl-kappaN1,kappaN4,kappaN7,kappaN10)tetrakis(methylene)]tetrakis(phosphonato-kappaO)](8-)]holmate(5-)-166Ho
CAS No. 633308-23-3
项目整合开发状态: Phase III
项目研究机构: International Isotopes (Supplier), NeoRx (Orphan Drug), Aventis Pharma (Originator), NeoRx (Licensee)
合成路线:The reaction of 1,4,7,10-tetraazacyclododecane (I) with formaldehyde and phosphoric acid in refluxing aqueous HCl gives the tetraphosphonic acid (II),which is then treated with aqueous 166HoCl3 to obtain the target chelate.