项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

EF-4040, ME-3407

Chemical Name: 2-(Butoxycarbonylmethylsulfinyl)thiazolo[5,4-b]pyridine; 2-(Thiazolo[5,4-b]pyridin-2-ylsulfinyl)acetic acid butyl ester
CAS No. 133903-90-9
项目整合开发状态: Phase II
项目研究机构: Meiji Sei...
参考文献标题:Azole derivs.and antiulcerative compsn.containing same
文献作者:Katano,K.; Tomomoto,T.; Ogino,H.; Yamazaki,N.; Hirano,F.; Yuda,Y.; Konno,F.; Nishio,M.; Machinami,T.; Shibahara,S.; Tsuruoka,T.; Inouye,S.(Meiji Seika Kaisha,Ltd.)
参考来源:EP 0405976; JP 1991218377; US 5079255; US 5141946; US 5200407

WAY-100289

Chemical Name: endo-2-(Cyclopropylmethoxy)-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-ylcarbamoyl)benzamide maleate; endo-1-[2-(Cyclopropylmethoxy)benzoyl]-3-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)urea m...
参考文献标题:Aroyl-ureas
文献作者:Ward,T.J.; White,J.C.; Bradley,G.(John Wyeth & Brother Ltd.)
参考来源:AU 9163749; EP 0422846; GB 2236528; JP 1991133986

Pibrozelesin hydrochloride, KW-2189

Chemical Name: 8(S)-(Bromomethyl)-2-methyl-4-(4-methylpiperazin-1-ylcarbonyloxy)-6-(5,6,7-trimethoxyindol-2-ylcarbonyl)-3,6,7,8-tetrahydrobenzo[1,2-b:4,3-b']dipyrrole-1-carboxylic acid methyl ester hy...
参考文献标题:DC-88A derivs
文献作者:Kanda,Y.; Uosaki,Y.; Saito,H.; Sano,H.; Kobayashi,E.; Morimoto,M.; Nagamura,S.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:EP 0406749; JP 1991128379; US 5070092; US 5187186

Domitroban calcium hydrate, S-1452, Anboxan

Chemical Name: (+)-5(Z)-(1R,2S,3S,4S)-7-[3-(Phenylsulfonylamino)bicyclo[2.2.1]hept-2-yl]heptenoic acid calcium salt dihydrate; (+)-5(Z)-(1R,2S,3S,4S)-7-[3-(Benzenesulfonamido)bicyclo[2.2.1]hept-2-yl]h...
参考文献标题:Bicyclic sulfonamide derivs
文献作者:Watanabe,F.; Narisada,M.; Ohtani,M.; Hagishita,S.; Tsuri,T.; Seno,K.; Tsushima,T.; Kamata,S.; Kawada,K.; Haga,N.(Shionogi & Co.Ltd.)
参考来源:EP 0226346; GB 2184118; JP 1988139161; US 5043451; US 5043456

Pranedipine tartrate, Servier-12968, S-12968

Chemical Name: (-)-2-[2-(2-Aminoethoxy)ethoxymethyl]-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl 5-methyl diester L-(+)-tartrate
CAS No. 132194-66-2 (HCl)
项...
参考文献标题:Synthesis of two optically active calcium channel antagonists labelled with carbon-11 for in vivo cardiac PET imaging
文献作者:Doll? F.; Hinnen,F.; Valette,H.; Fuseau,C.; Duval,R.; P間lion,J.-L.; Crouzel,C.
参考来源:Bioorg Med Chem 1997,5(4),749

KW-3196

Chemical Name: 5-Deoxy-2-O-nitro-5-[4-(pyridin-3-ylcarbonyl)piperazin-1-yl]-1,4:3,6-dianhydro-L-iditol
CAS No. 134186-21-3
项目整合开发状态: Preclinical
项目研究机构: Kyowa Hakko (Originator)
合成路线:The p...
参考文献标题:Hexitol derivatives having vasodilative activity
文献作者:Suzuki,F.; Hayashi,H.; Kuroda,T.; Kubo,K.; Ikeda,J.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:EP 0393574; JP 1991218381; US 5053408

OPC-14117

Chemical Name: 7-Hydroxy-1-[2-[4-(3-methoxyphenyl)piperazin-1-yl]acetamido]-2,2,4,6-tetramethylindan; N-(7-Hydroxy-2,2,4,6-trimethylindan-1-yl)-2-[4-(3-methoxyphenyl)piperazin-1-yl]acetamide
CAS No...
参考文献标题:2,3-Dihydro-1H-indene derivs.,a process for preparing them and pharmaceutical compsns.containing same
文献作者:Oshiro,Y.; Ueda,H.; Nakagawa,K.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:EP 0173331; ES 8800121; ES 8800884; ES 8801180; JP 1986069747; JP 1987129258; JP 1993004950; US 4788130; US 4895847; US 5242919

Sch-40338

Chemical Name: (?-11-(1-Acetyl-4-piperazinyl)-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine; (?-1-Acetyl-4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine<...
参考文献标题:Dual antagonists of platelet activating factor and histamine 3.Synthesis,biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines
文献作者:Piwinski,J.J.; Wong,J.K.; Green,M.J.; Kaminski,J.J.; Colizzo,F.; Albanese,M.M.; Ganguly,A.K.; Billah,M.M.; Anthes,J.C.; West,R.E.Jr.
参考来源:Bioorg Med Chem Lett 1998,8(24),3469

YM17E

Chemical Name: 1,3-Bis[1-cycloheptyl-3-[4-(dimethylamino)phenyl]ureidomethyl]benzene dihydrochloride; 1,1'-(1,3-Phenylene)bismethylenebis[1-cycloheptyl-3-[4-(dimethylamino)phenyl]urea] dihydrochloride...
参考文献标题:Diurea derivatives useful as medicaments and processes for the preparation thereof
文献作者:Ito,N.; Yasunaga,T.; Iizumi,Y.; Araki,T.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:AU 8928669; EP 0325397; JP 1990117651; US 5091419; US 5166429; US 5384425

BMY-43351

Chemical Name: 7-[4-[4-(Cyclohexylmethyl)piperazin-1-yl]-4-oxobutoxy]-2,3-dihydro-1H-imidazo[4,5-b]quinolin-2-one dihydrochloride; 1-(Cyclohexylmethyl)-4-[4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinoli...
参考文献标题:BMY 43351
文献作者:Russell,J.W.; Seiler,S.M.; Meanwell,N.A.; Fleming,J.S.
参考来源:Drugs Fut 1992,17(1),15