项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

IPM-[125I], [125I]-IPM

Chemical Name: N-(4-[125I]-Iodophenyl)maleimide; 1-(4-[125I]-Iodophenyl)pyrroline-2,5-dione
CAS No. 117207-47-3
项目整合开发状态: Preclinical
项目研究机构: Oak Ridge National Laboratory (Originator), Unive...
参考文献标题:Radioiodinated maleimides and use as agents for radiolabeling antibodies
文献作者:Srivastava,P.C.(US Department of Energy)
参考来源:US 4735792

A-70826

Chemical Name: (?-1-(2,4-Difluorophenyl)-6-fluoro-7-[3-(L-norvalyl-L-norvalylamino)pyrrolidin-1-yl]-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid hydrochloride
CAS No. 129670-72-0 (free bas...
参考文献标题:Synthesis and biological properties of A-70826: A prodrug of tosufloxacin
文献作者:Chu,D.T.W.; Pernet,A.G.; Plattner,J.J.; Hallas,R.; Shipkowitz,N.; Marsh,K.C.
参考来源:31st Intersci Conf Antimicrob Agents Chemother (Sept 29-Oct 2,Chicago) 1991,Abst 1440

L-695256

Chemical Name: (5R,6S)-6-[1(R)-Hydroxyethyl]-2-[7-(1-methylimidazolium-3-ylmethyl)-9-oxofluoren-3-yl]-1-carba-2-penem-3-carboxylate
CAS No. 137323-79-6
项目整合开发状态: Preclinical
项目研究机构: Merck & C...
参考文献标题:2-(9-Fluorenonyl)-carbapenem antibacterial agents
文献作者:Greenlee,M.L.; Dininno,F.P.; Cama,L.D.; Heck,J.V.(Merck & Co.,Inc.)
参考来源:EP 0472306; JP 1993105679; US 5034384

BIMU-8

Chemical Name: 3-Isopropyl-N-(endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-2,3-dihydro-1H-benzimidazole-1-carboxamide hydrochloride
CAS No. 134296-40-5
项目整合开发状态: Biological Testing
项目研究机构...
参考文献标题:Azabicycloalkyl benzimidazolone derivatives: A novel class of 5-HT3 receptor antagonists
文献作者:Turconi,M.; et al.
参考来源:199th ACS Natl Meet (April 22 1990,Boston) 1990,Abst MEDI 103

Disalazine, VUFB-17259

Chemical Name: 2-Acetoxy-5-[4-[N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo]benzoic acid
CAS No. 146404-38-8
项目整合开发状态: Preclinical
项目研究机构: Res. Inst. Pharmacy Biochemistry (VUFB) (Origin...
参考文献标题:Disalazine
文献作者:Kuchar,M.
参考来源:Drugs Fut 1992,17(2),98

F-1394

Chemical Name: N-(2,2,5,5-Tetramethyl-1,3-dioxan-4-ylcarbonyl)-beta-alanine 2(S)-[N'-(2,2-dimethylpropyl)-N'-nonylureido]-1(S)-cyclohexyl ester
CAS No. 135392-43-7
项目整合开发状态: Discontinued
项目研究...
参考文献标题:Pantothenic acid derivs
文献作者:Ikawa,H.; Matsumoto,H.; Kobayashi,N.; Kusunoki,J.(UCB Japan)
参考来源:EP 0421441; JP 1991218340; JP 1991218350; JP 1991218366; US 5120738

BTA-243, CL-316243(former code)

Chemical Name: (R,R)-5-[2-[2-(3-Chlorophenyl)-2-hydroxyethylamino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
CAS No. 138908-40-4, 138908-41-5 ((S, S)-isomer), 151126-84-0 (CL-3162...
参考文献标题:CL 316,243
文献作者:Bloom,J.D.; Claus,T.H.
参考来源:Drugs Fut 1994,19(1),23

N-0861

Chemical Name: (?-N6-(endo-2-Norbornyl)-9-methyladenine; (?-N6-(Bicyclo[2.2.1]hept-2-yl)-9-methyladenine; (?-endo-N-(Bicyclo[2.2.1]hept-2-yl)-9-methyl-9H-purin-6-amine
CAS No. 121252-55-9, 121241-8...
参考文献标题:N-0861
文献作者:Peck,J.V.; Cusack,N.J.
参考来源:Drugs Fut 1993,18(5),433

新产品编号:987677

Chemical Name: (5Z,7E)-(3S,23S,25R)-1,3beta,25-Trihydroxy-9,10-seco-5,7,10(19)-cholestatrieno-26,23-lactone; (1alpha,3beta,5Z,7E,23S,25R)-1,3,23,25-Tetrahydroxy-9,10-secocholesta-5,7,10(19)-trien-26-o...
参考文献标题:23(S),25(R)-1alpha,25-(OH)2-D3-26,23-Lactone
文献作者:Seino,Y.; Ishizuka,S.
参考来源:Drugs Fut 1992,17(8),655

DAU-6285

Chemical Name: 6-Methoxy-2-oxo-2,3-dihydro-1H-benzimidazole-1-carboxylic acid (endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrochloride
CAS No. 123258-98-0
项目整合开发状态: Preclinical
项目研究机构:...
参考文献标题:Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists
文献作者:Turconi,M.; Nicola,M.; Quintero,M.G.; Maiocchi,L.; Micheletti,R.; Giraldo,E.; Donetti,A.
参考来源:J Med Chem 1990,33(8),2101