IPM-[125I], [125I]-IPM
Chemical Name: N-(4-[125I]-Iodophenyl)maleimide; 1-(4-[125I]-Iodophenyl)pyrroline-2,5-dione
CAS No. 117207-47-3
项目整合开发状态: Preclinical
项目研究机构: Oak Ridge National Laboratory (Originator), University of Alabama at Birmingham (Originator)
合成路线:The radioiodination procedure (scheme 17660801a) has been described earlier (1,2) and was adapted for the synthesis of (II) as follows: Compound (I) (4.3 mg,10 mcmol) was added to Na125I (1.5 mCi) contained in 0.1 N NaOH (100 mcl) in a round-bottom flask shielded from light.N-Chlorosuccinimide (0.4 mg,3 mcmol) in THF (100 mcl) and sodium iodide (0.37 mg,2.5 mcmol) in water (100 mcl) were then added,and the solution was stirred at room temperature in the dark for 40 min.Sodium thiosulfate (2.5 mg) in water (1 ml) was then added.Extraction with ethyl ether and purification by silica gel column chromatography yielded [125I]-IPM (II) in 25% radiochemical yield (375 mcCi) with a calculated specific activity of 1.5 Ci/mmol (Srivastava,P.C.et al.NucCompact 1989,5: 145-9).
📌 参考资料/链接：
参考文献标题:Radioiodinated maleimides and use as agents for radiolabeling antibodies
文献作者:Srivastava,P.C.(US Department of Energy)
参考来源:US 4735792
📄 详细内容
合成路线:The radioiodination procedure (scheme 17660801a) has been described earlier (1,2) and was adapted for the synthesis of (II) as follows: Compound (I) (4.3 mg,10 mcmol) was added to Na125I (1.5 mCi) contained in 0.1 N NaOH (100 mcl) in a round-bottom flask shielded from light.N-Chlorosuccinimide (0.4 mg,3 mcmol) in THF (100 mcl) and sodium iodide (0.37 mg,2.5 mcmol) in water (100 mcl) were then added,and the solution was stirred at room temperature in the dark for 40 min.Sodium thiosulfate (2.5 mg) in water (1 ml) was then added.Extraction with ethyl ether and purification by silica gel column chromatography yielded [125I]-IPM (II) in 25% radiochemical yield (375 mcCi) with a calculated specific activity of 1.5 Ci/mmol (Srivastava,P.C.et al.NucCompact 1989,5: 145-9).
参考文献标题:Mercuric acetate phenylmaleimide useful for preparing radiohalogenated maleimides
文献作者:Srivastava,P.C.(US Department of Energy)
参考来源:US 4812577
合成路线:The radioiodination procedure (scheme 17660801a) has been described earlier (1,2) and was adapted for the synthesis of (II) as follows: Compound (I) (4.3 mg,10 mcmol) was added to Na125I (1.5 mCi) contained in 0.1 N NaOH (100 mcl) in a round-bottom flask shielded from light.N-Chlorosuccinimide (0.4 mg,3 mcmol) in THF (100 mcl) and sodium iodide (0.37 mg,2.5 mcmol) in water (100 mcl) were then added,and the solution was stirred at room temperature in the dark for 40 min.Sodium thiosulfate (2.5 mg) in water (1 ml) was then added.Extraction with ethyl ether and purification by silica gel column chromatography yielded [125I]-IPM (II) in 25% radiochemical yield (375 mcCi) with a calculated specific activity of 1.5 Ci/mmol (Srivastava,P.C.et al.NucCompact 1989,5: 145-9).
参考文献标题:[125I]-IPM
文献作者:Srivastava,P.C.; Buchsbaum,D.J.
参考来源:Drugs Fut 1991,16(11),1004