Disalazine, VUFB-17259
Chemical Name: 2-Acetoxy-5-[4-[N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo]benzoic acid
CAS No. 146404-38-8
项目整合开发状态: Preclinical
项目研究机构: Res. Inst. Pharmacy Biochemistry (VUFB) (Originator)
合成路线:Diazotization of 4-[N-(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]aniline (I) by means of sodium nitrite in diluted hydrochloric acid gives a corresponding diazonium salt (II),which is then reacted with salicylic acid (III) to afford the 2-hydroxy intermediate (IV).Disalazine is obtained by the reaction of (IV) with acetic anhydride or acetyl chloride.
📌 参考资料/链接：
参考文献标题:Disalazine
文献作者:Kuchar,M.
参考来源:Drugs Fut 1992,17(2),98
📄 详细内容
合成路线:Diazotization of 4-[N-(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]aniline (I) by means of sodium nitrite in diluted hydrochloric acid gives a corresponding diazonium salt (II),which is then reacted with salicylic acid (III) to afford the 2-hydroxy intermediate (IV).Disalazine is obtained by the reaction of (IV) with acetic anhydride or acetyl chloride.
参考文献标题:5-((4-(4,6-Dimethyl-2-pyrimidinylsulfamoyl)phenyl)azo)acetylsalicylic acid
文献作者:Kejha,J.; et al.
参考来源:Czech Appl 1426-91 (1991); Eur Pat Appl 91 117 064.5
合成路线:Diazotization of 4-[N-(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]aniline (I) by means of sodium nitrite in diluted hydrochloric acid gives a corresponding diazonium salt (II),which is then reacted with salicylic acid (III) to afford the 2-hydroxy intermediate (IV).Disalazine is obtained by the reaction of (IV) with acetic anhydride or acetyl chloride.
参考文献标题:Azo compounds of sulfonamides and hydroxy benzoic acids
文献作者:Kejha,J.; et al.
参考来源:Czech.Appl.6722-87