Sch-40338
Chemical Name: (?-11-(1-Acetyl-4-piperazinyl)-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine; (?-1-Acetyl-4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine
CAS No. 117796-62-0
项目整合开发状态: Preclinical
项目研究机构: Schering-Plough (Originator)
合成路线:Benzocycloheptapyridinone (I) was reduced to alcohol (II) with NaBH4 in MeOH.Subsequent treatment of (II) with SOCl2 in toluene gave the tricyclic chloride (III).Finally,alkylation of N-acetyl piperazine (IV) with chloride (III) in the presence of Et3N in boiling THF provided the title compound.
📌 参考资料/链接：
参考文献标题:Dual antagonists of platelet activating factor and histamine 3.Synthesis,biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines
文献作者:Piwinski,J.J.; Wong,J.K.; Green,M.J.; Kaminski,J.J.; Colizzo,F.; Albanese,M.M.; Ganguly,A.K.; Billah,M.M.; Anthes,J.C.; West,R.E.Jr.
参考来源:Bioorg Med Chem Lett 1998,8(24),3469