EF-4040, ME-3407
Chemical Name: 2-(Butoxycarbonylmethylsulfinyl)thiazolo[5,4-b]pyridine; 2-(Thiazolo[5,4-b]pyridin-2-ylsulfinyl)acetic acid butyl ester
CAS No. 133903-90-9
项目整合开发状态: Phase II
项目研究机构: Meiji Seika (Originator)
合成路线:2-Mercaptothiazolo[5,4-b]pyridine (I) is treated with chloroacetic acid butyl ester (II) in the presence of potassium carbonate in DMF to give 2-[(butoxycarbonylmethyl)thio]thiazolo[5,4-b]pyridine (III),which is oxidized with m-chloroperbenzoic acid in dichloromethane.
📌 参考资料/链接：
参考文献标题:Azole derivs.and antiulcerative compsn.containing same
文献作者:Katano,K.; Tomomoto,T.; Ogino,H.; Yamazaki,N.; Hirano,F.; Yuda,Y.; Konno,F.; Nishio,M.; Machinami,T.; Shibahara,S.; Tsuruoka,T.; Inouye,S.(Meiji Seika Kaisha,Ltd.)
参考来源:EP 0405976; JP 1991218377; US 5079255; US 5141946; US 5200407
📄 详细内容
合成路线:2-Mercaptothiazolo[5,4-b]pyridine (I) is treated with chloroacetic acid butyl ester (II) in the presence of potassium carbonate in DMF to give 2-[(butoxycarbonylmethyl)thio]thiazolo[5,4-b]pyridine (III),which is oxidized with m-chloroperbenzoic acid in dichloromethane.
参考文献标题:ME-3407
文献作者:Castar,J.; Mealy,N.; Prous,J.
参考来源:Drugs Fut 1994,19(1),31