合成路线:The preparation of KW-3196 is as follows: Reaction of 1,4:3,6-dianhydro-D-glucitol 5-methanesulfonate (I) (1) with piperazine (II) afforded (III),which was nitrated with fuming HNO3 to give the nitrate ester (IV).Nicotynoylation of (IV) gave KW-319).
参考文献标题:KW-3196
文献作者:Suzuki,F.
参考来源:Drugs Fut 1992,17(11),995
合成路线:The preparation of KW-3196 is as follows: Reaction of 1,4:3,6-dianhydro-D-glucitol 5-methanesulfonate (I) (1) with piperazine (II) afforded (III),which was nitrated with fuming HNO3 to give the nitrate ester (IV).Nicotynoylation of (IV) gave KW-319).
参考文献标题:Synthesis of stereoisomers of 1,4:3,6-dianhydrohexitol nitrate derivative,KF14124
文献作者:Ueno,H.; Hayashi,H.; Suzuki,F.
参考来源:Bioorg Med Chem Lett 1992,21187-92
合成路线:The preparation of KW-3196 is as follows: Reaction of 1,4:3,6-dianhydro-D-glucitol 5-methanesulfonate (I) (1) with piperazine (II) afforded (III),which was nitrated with fuming HNO3 to give the nitrate ester (IV).Nicotynoylation of (IV) gave KW-319).
参考文献标题:Alkylaminodeoxy-1,4:3,6-dianhydrohexitol nitrates substituted by purine bases and their pharmaceutical compositions
文献作者:Klessing,K.; Chatterjee,S.S.(Dr.Willmar Schwabe)
参考来源:EP 0044927
产品链接: CAS No. 134186-21-3››