项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Maxacalcitol, 22-Oxacalcitriol, Sch-209579, MC-1275, 22-Oxa-1,25(OH)2D3, OCT, Oxarol, Prezios

马沙骨化醇Chemical Name: 1alpha,25-Dihydroxy-22-oxavitamin D3; 22-Oxacalcitriol; 20(S)-(3-Hydroxy-3-methylbutoxy)-9,10-secopregna-5(Z),7(E),10(19)-trien-1alpha,3beta-diol
CAS No. 103909-75-7
项目整合开发状态...
参考文献标题:Novel vitamin D derivs.and process for producing the same
文献作者:Kubodera,N.; Miyamoto,K.; Ochi,K.; Matsunaga,I.; Murayama,E.(Chugai Pharmaceutical Co.Ltd.)
参考来源:EP 0184112; JP 1986267548; JP 1986267550

Malotilate, DA-3857, NKK-105, Tractal, Kantec

马洛替酯Chemical Name: Diisopropyl 1,3-dithiol-2-ylidenemalonate
CAS No. 59937-28-9
项目整合开发状态: Launched-1985
项目研究机构: Daiichi Pharmaceutical (Originator), Nihon Nohyaku (Originator), Roemmers (Lice...
参考文献标题:1,3-Dithiol-2-ylidene malonic esters
文献作者:Kurono,H.; Hirano,A.; Taninaka,K.(Nihon Nohyaku Co.,Ltd.)
参考来源:DE 2545569; US 4035387

Mafosfamide cyclohexylamine salt, ASTA-Z-7654(free acid), NSC-345842, ASTA-Z-7557

马磷酰胺Chemical Name: 2-[2-Bis(2-chloroethyl)amino-2-oxo-tetrahydro-2H-1,3,2-oxazaphosphorine-4-ylthio]ethanesulfonic acid cyclohexylamine salt; 2-[Bis(2-chloroethyl)amino]-4-(2-sulfoethylthio)tetrahydro...
参考文献标题:Oxazaphosphorin-4-thio-alkanesulphonic acids,and neutral salts thereof
文献作者:Scheffler,G.; et al.(Asta Medica AG)
参考来源:BE 0892589

Mafoprazine mesylate, IK-640, Mafoprane

马福拉嗪Chemical Name: 1-[3-(4-Acetamido-2-methoxyphenoxy)propyl]-4-(2-fluorophenyl)piperazine methanesulfonate
CAS No. 80428-29-1 (free base)
项目整合开发状态: Phase I
项目研究机构: Sumitomo Pharmaceuticals (...
参考文献标题:N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial presssure
文献作者:Kanno,T.; Gaino,M.; Yamamura,M.; Ishida,R.; Shintomi,K.(Tanabe Seiyaku Co.,Ltd.)
参考来源:EP 0034284; JP 156115769; US 4413006

Marimastat, TA-2516, BB-2516

马立马司他Chemical Name: N1-[2,2-Dimethyl-1(S)-(N-methylcarbamoyl)propyl]-N4,3(S)-dihydroxy-2(R)-isobutylsuccinamide; 3(R)-[N-[2,2-Dimethyl-1(S)-(N-methylcarbamoyl)propyl]carbamoyl]-2(S)-hydroxy-5-methylhe...
参考文献标题:Natural amino acid derivs.as metalloproteinase inhibitors
文献作者:Dickens,J.P.; Crimmin,M.J.; Beckett,R.P.(British Biotech plc)
参考来源:EP 0651738; EP 0651739; GB 2268933; GB 2268934; JP 1995509460; JP 1998204081; WO 9402446; WO 9402447

Irisquinone A, Irisquinone, Iq-7611

马蔺子甲素Chemical Name: 2-[10(Z)-Heptadecenyl]-6-methoxy-1,4-benzoquinone
CAS No. 56495-82-0
项目整合开发状态: Phase III
项目研究机构: Shandong Xinghua (Originator), Shanghai Inst. Pharm. Ind. (Originator), Ti...
参考文献标题:Chemical studies of Iris pallasii Fisch.var.chinensis Fisch.
文献作者:Wu,S.J.; Yang,Q.Z.
参考来源:Acta Chim Sin 1980,38(2),156

ZD-3523

马鲁司特 1H-吲哚-5-羧酰胺,3-[[[2-甲氧基-4-[(2-甲基苯基)磺酰]氨基]羰基]苯基]甲基]-1-甲基-N-(4,4,4-三氟-2-甲基丁基)- Chemical Name: (R)-3-Methoxy-4-[1-methyl-5-[N-(2-methyl-4,4,4-trifluorobutyl)carbamoyl]indol-3-ylmethyl]-N-(2-methylphe...
参考文献标题:A process for the preparation of a 3-alkylated indole,intermediates,and a process for the preparation of a derivative thereof
文献作者:Jacobs,R.T.; Costello,G.F.; Brook,S.A.; Harrison,P.J.(AstraZeneca plc)
参考来源:EP 0489547

Homoharringtonine, CGX-635-14 (formulation), CGX-635, NSC-141633, HHT, ZJ-C, Myelostat, Ceflatonin

高三尖杉酯碱Chemical Name: 2(R)-(Methoxycarbonylmethyl)-2,6-dihydroxy-5-methylheptanoic cephalotaxine ester
CAS No. 26833-87-4
项目整合开发状态: Phase II
项目研究机构: Chinese Academy of Medical Sciences (Origin...
参考文献标题:Novel cephalotaxane derivs.and process for their preparation
文献作者:Robin,J.; Robin,J.-P.; Cavoleau,S.; Chauviat,L.; Charbonnel,S.; Dhal,R.; Dujardin,G.; Fournier,F.; Gilet,C.; Girodier,L.; Mevelec,L.; Poutot,S.; Rouaud,S.(OncoPharm Corp.)
参考来源:EP 1064285; FR 2776292; WO 9948894

Podofilox, Podophyllotoxin, Wartec, Condyline, Condylox

鬼臼毒素Chemical Name: (5R,5aR,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
CAS No. 518-28-5
项目整合开发状态: Launched-1985
项目研究机构:...
参考文献标题:Enzyme-assisted asymmetric total synthesis of (-)-podophyllotoxin and (-)-picropodophyllin
文献作者:Berkowitz,D.B.; Choi,S.; Maeng,J.H.
参考来源:J Org Chem 2000,65(3),847

Lufironil, Hoe-077

鲁非罗尼Chemical Name: N,N'-Bis(2-methoxyethyl)-2,4-pyridinedicarboxamide
CAS No. 128075-79-6
项目整合开发状态: Phase II
项目研究机构: Aventis Pharma (Originator)
合成路线:Lufironil is obtained by treatment of ...
参考文献标题:Pyridine-2,4- and 2,5-dicarboxydi(nitroxyalkyl)amides,processes for their preparation,and their use
文献作者:Baader,E.(Aventis SA)
参考来源:DE 4001002; EP 0438795; JP 1992330060