Lufironil, Hoe-077
鲁非罗尼Chemical Name: N,N'-Bis(2-methoxyethyl)-2,4-pyridinedicarboxamide
CAS No. 128075-79-6
项目整合开发状态: Phase II
项目研究机构: Aventis Pharma (Originator)
合成路线:Lufironil is obtained by treatment of 2,4-pyridinedicarboxylic acid (I) with thionyl chloride in toluene,followed by reaction with 2-methoxyethylamine,either in dioxane (1) or in toluene in the presence of triethylamine.
📌 参考资料/链接：
参考文献标题:Pyridine-2,4- and 2,5-dicarboxydi(nitroxyalkyl)amides,processes for their preparation,and their use
文献作者:Baader,E.(Aventis SA)
参考来源:DE 4001002; EP 0438795; JP 1992330060
📄 详细内容
合成路线:Lufironil is obtained by treatment of 2,4-pyridinedicarboxylic acid (I) with thionyl chloride in toluene,followed by reaction with 2-methoxyethylamine,either in dioxane (1) or in toluene in the presence of triethylamine.
参考文献标题:Improved process of preparation of N,N-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid amides
文献作者:Baader,E.; Burghard,H.; Bickel,M.; Guenzler-Pukall,V.(Aventis SA)
参考来源:EP 0353668
合成路线:Lufironil is obtained by treatment of 2,4-pyridinedicarboxylic acid (I) with thionyl chloride in toluene,followed by reaction with 2-methoxyethylamine,either in dioxane (1) or in toluene in the presence of triethylamine.
参考文献标题:Lufironil
文献作者:Prous,J.; Castar,J.; Mealy,N.
参考来源:Drugs Fut 1993,18(8),704
产品链接: CAS No. 128075-79-6››