Mafosfamide cyclohexylamine salt, ASTA-Z-7654(free acid), NSC-345842, ASTA-Z-7557
马磷酰胺Chemical Name: 2-[2-Bis(2-chloroethyl)amino-2-oxo-tetrahydro-2H-1,3,2-oxazaphosphorine-4-ylthio]ethanesulfonic acid cyclohexylamine salt; 2-[Bis(2-chloroethyl)amino]-4-(2-sulfoethylthio)tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide cyclohexylamine salt; 4-Sulfoethylthiocyclosphosphamide cyclohexylamine salt
CAS No. 88859-04-5 (free acid)
项目整合开发状态: Phase II
项目研究机构: Baxter Oncology (Originator)
合成路线:Z-7557 can be prepared from 4-hydroxycyclophosphamide (I) and 2-mercaptoethanesulfonic acid cyclohexylamine salt (II) in water/acetone.
📌 参考资料/链接：
参考文献标题:Oxazaphosphorin-4-thio-alkanesulphonic acids,and neutral salts thereof
文献作者:Scheffler,G.; et al.(Asta Medica AG)
参考来源:BE 0892589
📄 详细内容
合成路线:Z-7557 can be prepared from 4-hydroxycyclophosphamide (I) and 2-mercaptoethanesulfonic acid cyclohexylamine salt (II) in water/acetone.
参考文献标题:
文献作者:Iwata,T.; Yamaguchi,K.; Takamizawa,A.; Katagiri,K.; Matsumoto,S.; Tochino,Y.
参考来源:J Am Chem Soc 1973,98985
合成路线:Z-7557 can be prepared from 4-hydroxycyclophosphamide (I) and 2-mercaptoethanesulfonic acid cyclohexylamine salt (II) in water/acetone.
参考文献标题:ASTA-Z-7557
文献作者:Castar,J.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1983,8(10),873
产品链接: CAS No. 88859-04-5››