项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Febuxostat, TMX-67, TEI-6720

非布索坦Chemical Name: 2-(3-Cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
CAS No. 144060-53-7
项目整合开发状态: Pre-Registered
项目研究机构: Teijin (Originator), Ipsen (Licensee), TAP (Licensee)<...
参考文献标题:2-Arylthiazole deriv.and pharmaceutical compsn.containing the same
文献作者:Kondo,S.; Fukushima,H.; Hasegawa,M.; Tsuchimoto,M.; Nagata,I.; Osada,Y.; Komoriya,K.; Yamaguchi,H.(Teijin Ltd.)
参考来源:EP 0513379; JP 1993500083; US 5614520; WO 9209279

Fexinidazole, Hoe-239

非昔硝唑Chemical Name: 1-Methyl-2-[4-(methylsulfanyl)phenoxymethyl]-5-nitro-1H-imidazole
CAS No. 59729-37-2
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:By condensation of 4-(methylmercapto)phen...
参考文献标题:Chemotherapeutically active nitro compounds.4,5-Nitroimidazoles.Part III
文献作者:Winkelman,E.; Raether,W.
参考来源:Arzneim-Forsch Drug Res 1978,28(5),739

Fepradinol, EL-508(HCl), Flexidol, Dalgen

非普地醇Chemical Name: (?-alpha-[[(2-Hydroxy-1,1-dimethylethyl)amino]methyl]benzyl alcohol; (?-2-(2-Hydroxy-1,1-dimethylethylamino)-1-phenylethanol; (?-N-(1-Hydroxy-2-methyl-2-propyl)-2-hydroxy-2-phenylet...
参考文献标题:2-[N-(2-Hydroxy-1,1-dimethylethyl)amino]-1-phenylethanol which is useful,in particular,as an anti-inflammatory,and process for preparing it
文献作者:Montoro,F.; Calatayud,J.; Luna,M.(Byk Elmu SA)
参考来源:CH 670823; FR 2573071; JP 1986143344

Felbamate, W-554, Felbamyl, Taloxa, Felbatol

非氨酯Chemical Name: 2-Phenyl-1,3-propanediol dicarbamate
CAS No. 25451-15-4
项目整合开发状态: Launched-1993
项目研究机构: MedPointe (Originator), National Institute of Mental Health (Not Determined), Scherin...
参考文献标题:Felbamate
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(11),931

Felodipine, H-154/82, CGH-869, Prevex, Perfudal, Lexxel(Comb. with enalapril), Logimax, Splendil, Munobal, Modip, Flodil, Plendil, Hydac

非洛地平非洛地平 Chemical Name: (?-4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ethyl methyl diester; (?-4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3-ethoxycarbonyl-5-me...
参考文献标题:2,6-Dimethyl-4-2,3-disubstituted phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid-3,5-asymmetric diesters having hypotensive properties,as well as method for treating hypertensive conditions and pharmaceutical preparations containing same
文献作者:Bernston,P.B.; Carlsson,S.A.I.; Gaarder,J.O.; Ljung,B.R.(AstraZeneca AB)
参考来源:CA 1117530; EP 0007293; JP 55009083; US 4264611

Femoxetine, NNC-20-4963, FG-4963(HCl)

非莫西汀Chemical Name: (+)-(3R,4S)-3-[(4-Methoxyphenoxy)methyl]-1-methyl-4-phenylpiperidine
CAS No. 59859-58-4
项目整合开发状态: Phase III
项目研究机构: Ferrosan A/S (Originator)
合成路线:The reaction of methyl...
参考文献标题:Femoxetine
文献作者:Chatterjee,S.S.
参考来源:Drugs Fut 1977,2(5),309

Fiacitabine, FIAC

非西他滨Chemical Name: 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine; 2'-Deoxy-2'-fluoro-5-iodocytarabine; 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-2(1H)-pyrimidinone
C...
参考文献标题:FIAC
文献作者:Thorpe,P.J.; Castar,J.
参考来源:Drugs Fut 1981,6(7),410

Fidarestat, SNK-860, Aldos

非达司他螺内酯[4H-1-苯并吡喃-4,4'-咪唑烷]-2-羧酰胺,6-氟-2,3-二氢-2',5'-二氧基-Chemical Name: (2S,4S)-6-Fluoro-2',5'-dioxospiro[3,4-dihydro-2H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide
CAS No. 136087-85-9, 118803-58-...
参考文献标题:Hydantoin derivs.for treating complications of diabetes
文献作者:Kurono,M.; Kondo,Y.; Yamaguchi,T.; Miura,K.; Usui,T.; Terada,N.; Asano,K.; Mizuno,K.; Matsubara,A.; Kato,N.; Sawai,K.; Unno,R.; Ozawa,H.; Fukushima,M.(Sanwa Kagaku Kenkyusho Co.,Ltd.)
参考来源:EP 0264586; JP 1988057588; JP 1988126881; JP 1988250373; US 4861792; US 4978758; US 5447946

Finasteride, YM-152, MK-906, Prodel, Propecia, Chibro-Proscar, Finastid, Prostide, Andozac, Proscar

非那雄胺Chemical Name: 17beta-(N-tert-Butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one; N-tert-Butyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
CAS No. 98319-26-7
项目整合开发状态: Launched-1992
...
参考文献标题:17beta-Substd.-4-aza-5alpha-androstenones and their use as 5alpha-reductase inhibitors
文献作者:Rasmusson,G.H.; Reynolds,G.F.(Merck & Co.,Inc.)
参考来源:AU 8539167; EP 0155096; EP 0314199; ES 8702430; JP 1985222497; JP 1989093600; US 4760071

Ellagic acid

鞣花酸Chemical Name: 2,3,7,8-Tetrahydroxy[1]benzopyrano[5,4,3-cde][1]- benzopyran-5,10-dione
CAS No. 476-66-4
项目整合开发状态: Preclinical
项目研究机构: Aldrich (Supplier), Sigma Chemical (Supplier)
合成路线:...
参考文献标题:Ellagic acid
文献作者:Cheng,C.C.; Zee-Cheng,R.K.-Y.
参考来源:Drugs Fut 1986,11(12),1029