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项目整合精选>>>Felodipine, H-154/82, CGH-869, Prevex, Perfudal, Lexxel(Comb. with enalapril), Logimax, Splendil, Munobal, Modip, Flodil, Plendil, Hydac
Felodipine, H-154/82, CGH-869, Prevex, Perfudal, Lexxel(Comb. with enalapril), Logimax, Splendil, Munobal, Modip, Flodil, Plendil, Hydac
非洛地平 非洛地平 Chemical Name: (?-4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ethyl methyl diester; (?-4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3-ethoxycarbonyl-5-methoxycarbonylpyridine
CAS No. 86189-69-7, 72509-76-3 (undefined stereoch.)
项目整合开发状态: Launched-1988
项目研究机构: Asta Medica (Originator), AstraZeneca (Originator), Aventis Pharma (Originator), Kissei (Licensee), Merck & Co. (Licensee), Novartis (Licensee), Promed (Licensee)
合成路线:By cyclization of methyl 2,3-dichlorobenzyldeneacetoacetate (I) with ethyl 3-aminocrotonate (II) in tert-butanol at room temperature.
合成路线:By cyclization of 2,3-dichlorobenzaldehyde (I) with 3-aminocrotonic acid ethyl ester (II) and acetylacetic acid methyl ester (III) in refluxing ethanol.
合成路线:By cyclization of 2-(2,3-dichlorobenzylidene)acetyl acetic acid methyl ester (IV) with acetylacetic acid ethyl ester (V) and ammonia (VI) in tert-butanol.
📌 参考资料/链接：
参考文献标题:2,6-Dimethyl-4-2,3-disubstituted phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid-3,5-asymmetric diesters having hypotensive properties,as well as method for treating hypertensive conditions and pharmaceutical preparations containing same
文献作者:Bernston,P.B.; Carlsson,S.A.I.; Gaarder,J.O.; Ljung,B.R.(AstraZeneca AB)
参考来源:CA 1117530; EP 0007293; JP 55009083; US 4264611
📄 详细内容
合成路线:By cyclization of methyl 2,3-dichlorobenzyldeneacetoacetate (I) with ethyl 3-aminocrotonate (II) in tert-butanol at room temperature.
参考文献标题:Felodipine
文献作者:Blancafort,P.; Serradell,M.N.; Sneddon,J.M.; Castar,J.
参考来源:Drugs Fut 1982,7(3),160
合成路线:By cyclization of methyl 2,3-dichlorobenzyldeneacetoacetate (I) with ethyl 3-aminocrotonate (II) in tert-butanol at room temperature.
参考文献标题:Determination of te conformation of felodipine by 1H NMR-spinlattice relaxation time measurements
文献作者:Carter,R.E.; Berntsson,P.
参考来源:Acta Pharm Suec 1981,18221-226
产品链接: CAS No. 86189-69-7›› 产品链接: CAS No.72509-76-3››