项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Cisatracurium besylate, Cisatracurium besilate, (1R-cis,1'R-cis)-Atracurium besylate, 51W89, Nimbex Forte, Nimbex

顺苯磺阿曲库铵Chemical Name: (1R-cis,1'R-cis)-2,2'-(4,10-Dioxa-3,11-dioxo-1,13-tridecylene)bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] bis(benzenesulfonate)
CAS No...
参考文献标题:Neuromuscular blocking agents
文献作者:Hill,D.A.; Turner,G.L.(Glaxo Wellcome plc)
参考来源:CH 683427; EP 0539470; FR 2665791; GB 2260763; JP 1993508648; JP 1998139763; US 5453510; WO 9200965

Bucumolol

香豆心安Chemical Name: 8-[3-(tert-Butylamino)-2-hydroxypropoxy]-5-methyl-2H-1-benzopyran-2-one
CAS No. 58409-59-9
项目整合开发状态: Not Determined
项目研究机构:
合成路线:It can be prepared in three different,b...
参考文献标题:
文献作者:Sato,Y.; et al.
参考来源:US 3663570

Manidipine hydrochloride, Franidipine hydrochloride, CV-4093, Artedil, Iperten, Calslot

马尼地平马尼地平 Chemical Name: 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl diester dihydrochloride
CAS No. 120092-68-4...
参考文献标题:Dihydropyridine derivs.,their production and use
文献作者:Meguro,K.; Nagaoka,A.(Takeda Chemical Industries,Ltd.)
参考来源:EP 0138505; JP 1985084269; US 4603135

Enalapril maleate, MK-421, Ednit, Ditensor, Dabonal, Baripril, Crinoren, Xanef, Renitec, Enapren, Innovace, Innovace Melt(freeze-dried oral wafer), Lexxel(comb. with felodipine), Renivace, Vasotec

马来酸依那普利依那普利 Chemical Name: (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline maleate
CAS No. 76095-16-4, 75847-73-3 (free base)
项目整合开发状态: Launched-1984
项目研究机构: Merck & Co. (O...
参考文献标题:Enalapril maleate
文献作者:Hopkins,S.J.; Serradell,M.N.; Blancafort,P.; Castar,J.
参考来源:Drugs Fut 1982,7(8),556

Tegaserod maleate, HTF-919, SDZ-HTF-919, Zelnorm, Zelmac

马来酸替加色罗马来酸替加色罗 Chemical Name: 2-(5-Methoxy-1H-indol-3-ylmethylene)-N-pentylhydrazinecarboximidamide monomaleate; 1-(5-Methoxy-1H-indol-3-ylmethyleneamino)-3-pentylguanidine monomaleate
CAS No. 189...
参考文献标题:Aminoguanidines
文献作者:Giger,R.K.A.; Mattes,H.(Novartis AG; Novartis Deutschland GmbH)
参考来源:EP 0505322; US 5510353

Fluvoxamine maleate, SME-3110, MK-264, DU-23000, Luvox CR, Depromel, Luvox, Faverin, Fevarin, Floxyfral

马来酸氟伏沙明氟伏沙明 Chemical Name: 5-Methoxy-4'-(trifluoromethyl)valerophenone (E)-O-(2-aminoethyl)oxime maleate; 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone (E)-O-(2-aminoethyl)oxime maleate
CAS ...
参考文献标题:Fluvoxamine
文献作者:Thorpe,P.J.; Castar,J.
参考来源:Drugs Fut 1978,3(4),288

Flupirtine maleate, D-9998, Katadolon

马来酸氟吡汀氟吡汀 Chemical Name: 2-Amino-3-carbethoxyamino-6-(p-fluorobenzylamino)pyridine maleate
CAS No. 75507-68-5, 56995-20-1 (free base)
项目整合开发状态: Launched-1986
项目研究机构: Asta Medica (Originator)...
参考文献标题:Flupirtine
文献作者:Castar,J.; Serradell,M.N.; Blancafort,P.
参考来源:Drugs Fut 1983,8(9),773

Velnacrine maleate, P83-6029A, HP-029, Mentane

马来酸维吖啶Chemical Name: (?-9-Amino-1,2,3,4-tetrahydroacridin-1-ol maleate
CAS No. 118909-22-1, 112964-99-5 (former CAS), 121445-18-9 (former CAS), 104675-29-8 (free base), 112964-98-4 (free base, form...
参考文献标题:9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related cpds.,a process for their preparation and their use as medicaments
文献作者:Shutske,G.M.; Pierrat,F.A.(Aventis Pharmaceuticals,Inc.)
参考来源:AU 8549038; EP 0179383; ES 8701165; ES 8801213; ES 8802383; JP 1986148154; JP 1989125362; US 4631286; US 4839364

Rosiglitazone maleate, SB-206846((-)-enantiomer, free base), SB-210232((+)-enantiomer, free base), BRL-49653C, Venvia, Nyracta, Avandia

马来酸罗格列酮罗格列酮 Chemical Name: (?-5-[4-[2-[N-Methyl-N-(2-pyridyl)amino]ethoxy]benzyl]thiazolidine-2,4-dione maleate
CAS No. 155141-29-0, 122320-73-4 (free base)
项目整合开发状态: Launched-1999
项目研究机构: ...
参考文献标题:Substd.Thiazolidine-dione derivs
文献作者:Hindley,R.M.(SmithKline Beecham plc)
参考来源:AU 8821738; EP 0306228; EP 0842925; JP 1989131169; JP 1997183726; JP 1997183771; JP 1997183772; JP 1998194970; JP 1998194971; US 5002953; US 5194443; US 5232925; US 5646169

Coriariin A

马桑鞣素AChemical Name: Bis[2,3-O-bis(3,4,5-trihydroxybenzoyl)-4,6-O-cyclic(4,4',5,5',6,6'-hexahydroxybiphenyl-2,2'-dicarbonyl)-beta-D-glucopyranos-1-yl] diester with 2,3'-epoxy-3,4,4',5,5'-pentahydroxybi...
参考文献标题:Elagitannin chemistry.The first total synthesis of a dimeric ellagitannin,coriariin A
文献作者:Lawlor,M.D.; Feldman,K.S.
参考来源:J Am Chem Soc 2000,122(30),7396