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项目整合精选>>>Enalapril maleate, MK-421, Ednit, Ditensor, Dabonal, Baripril, Crinoren, Xanef, Renitec, Enapren, Innovace, Innovace Melt(freeze-dried oral wafer), Lexxel(comb. with felodipine), Renivace, Vasotec
Enalapril maleate, MK-421, Ednit, Ditensor, Dabonal, Baripril, Crinoren, Xanef, Renitec, Enapren, Innovace, Innovace Melt(freeze-dried oral wafer), Lexxel(comb. with felodipine), Renivace, Vasotec
马来酸依那普利 依那普利 Chemical Name: (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline maleate
CAS No. 76095-16-4, 75847-73-3 (free base)
项目整合开发状态: Launched-1984
项目研究机构: Merck & Co. (Originator), Merck Sharp & Dohme (Originator), Almirall Prodesfarma (Licensee), Banyu (Licensee), Uriach (Licensee), Vita (Licensee)
合成路线:By reductocondensation of ethyl 2-oxo-4-phenylbutyrate (I) with alanylproline (II) by means of sodium cyanoborohydride or H2 over Raney-Ni or Pd/C in water.
📌 参考资料/链接：
参考文献标题:Enalapril maleate
文献作者:Hopkins,S.J.; Serradell,M.N.; Blancafort,P.; Castar,J.
参考来源:Drugs Fut 1982,7(8),556
📄 详细内容
合成路线:By reductocondensation of ethyl 2-oxo-4-phenylbutyrate (I) with alanylproline (II) by means of sodium cyanoborohydride or H2 over Raney-Ni or Pd/C in water.
参考文献标题:A new class of angiotensin-converting anzyme inhibitors
文献作者:Patchett,A.A.; et al.
参考来源:Nature 1980,288280-283
产品链接: CAS No. 76095-16-4›› 产品链接: CAS No.75847-73-3››