项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Nicaraven, AVS, Antevas

烟拉文Chemical Name: 1,2-Bis(nicotinamido)propane; N-N'-(1-Methyl-1,2-ethanediyl)bis-3-pyridinecarboxamide
CAS No. 79455-30-4
项目整合开发状态: Pre-Registered
项目研究机构: Chugai (Originator), Novartis (Coma...
参考文献标题:Nicotinamide derivative,process dor preparing the same and pharmaceutical composition containing the same
文献作者:Mori,T.; Takaku,S.; Matsuura,F.; Murakami,Y.; Noda,Y.; Yamazaki,T.; Neichi,T.; Nakakimura,H.; Kataoka,S.(Chugai Pharmaceutical Co.Ltd.)
参考来源:EP 0029602; JP 56075474

L44-O

烟酸2-叔丁基-4-环己基苯基酯1-氧化物Chemical Name: 2-tert-Butyl-4-cyclohexylphenyl nicotinate N-oxide; 1-Oxidopyridine-3-carboxylic acid 4-cyclohexyl-2-(tert-butyl)phenyl ester
CAS No. 95240-93-0
项目整合开发状态: Pha...
参考文献标题:L44/L44-O
文献作者:Quack,G.
参考来源:Drugs Fut 1987,12(4),349

Altrenogest, DRC-6246, A-35957, RU-2267, RH-2267, Regumate

烯丙孕素Chemical Name: 17alpha-Allyl-17-hydroxyestra-4,9,11-trien-3-one
CAS No. 850-52-2
项目整合开发状态: Not Determined
项目研究机构:
合成路线:This compound can be prepared by two different ways:1) The Grign...
参考文献标题:
文献作者:Pierdet,A.; Vignau,M.
参考来源:FR M5183

Alinidine, ST-567-BR(hydrobromide), ST-567

烯丙尼定Chemical Name: 2-(N-Allyl-2,6-dichloroanilino)-2-imidazoline; N-Allyl-clonidine; 2-[N-Allyl-N-(2,6-dichlorophenyl)amino]-2-imidazoline
CAS No. 33178-86-8
项目整合开发状态: Phase III
项目研究机构: Boehr...
参考文献标题:Alinidine
文献作者:Castar,J.; Hopkins,S.J.
参考来源:Drugs Fut 1980,5(1),11

Epristeride, Ono-9302, SK&F-105657

爱普列特Chemical Name: 17beta-(N-tert-Butylcarbamoyl)androsta-3,5-diene-3-carboxylic acid; 17beta-[N-(1,1-Dimethylethyl)aminocarbonyl]androsta-3,5-diene-3-carboxylic acid
CAS No. 119169-78-7
项目整合开发状...
参考文献标题:Epristeride
文献作者:Levy,M.A.; Holt,D.A.; Wier,P.J.; Baine,N.H.; Audet,P.R.; Metcalf,B.W.; Benincosa,L.J.; Rappaport,E.B.
参考来源:Drugs Fut 1994,19(7),646

Alvimopan hydrate, ADL-8-2698, LY-246736 dihydrate, Entereg

爱维莫潘Chemical Name: (+)-2-[2(S)-Benzyl-3-[4(R)-(3-hydroxyphenyl)-3(R),4-dimethylpiperidin-1-yl]propionamido]acetic acid dihydrate
CAS No. 170098-38-1
项目整合开发状态: Pre-Registered
项目研究机构: Lilly (Or...
参考文献标题:Trisubstd.-piperidinyl-N-alkylcarboxylates as opioid antagonists
文献作者:Prather,D.E.; Werner,J.A.; Wad,J.A.; Frank,S.A.(Eli Lilly and Company)
参考来源:EP 0984004

Tauroursodeoxycholic acid, Ursodeoxycholyltaurine, UR-906

牛磺熊去氧胆酸Chemical Name: N-(3alpha,7beta-Dihydroxy-5beta-cholan-24-oyl)taurine
CAS No. 14605-22-2
项目整合开发状态: Phase II
项目研究机构: Mitsubishi Pharma (Originator), Children's Hosp. Med. Center, Cincinn...
参考文献标题:Process for preparing ursodeoxycholic acid derivates and their inorganic and organic salts having therapeutic activity
文献作者:Reiner,A.(SkyePharma AG)
参考来源:EP 0272462

Taurolidine, Taurolin

牛磺罗定Chemical Name: 4,4'-Methylenebis(tetrahydro-1,2,4-thiadiazine 1,1-dioxide); Bis(1,1-dioxoperhydro-1,2,4-thiadiazin-4-yl)methane
CAS No. 19388-87-5
项目整合开发状态: Launched-1988
项目研究机构: Boehring...
参考文献标题:Perhydro-1,2,4-thiadiazine-dioxydes-(1,1) et proc閐?pour leur pr閜aration
文献作者:Pfirrmann,R.W.(Geistlich)
参考来源:DE 1545912; FR 1458701; FR 4914M; GB 1124185; US 3423408

Tauromustine, TCNU, LS-2667, Tauricyt

牛磺莫司汀Chemical Name: 1-(2-Chloroethyl)-3-[2-(dimethylsulfamoyl)ethyl]-1-nitrosurea
CAS No. 85977-49-7
项目整合开发状态: Phase III
项目研究机构: Leo (Originator)
合成路线:1) N,N-Dimethyl-2-aminoethanesulfonam...
参考文献标题:N-nitroso compounds and compositions containing such compounds
文献作者:Carlsson,J.-I.; Jensen,P.H.G.; Stamvik,A.R.(Leo Pharma AB)
参考来源:EP 0106123; JP 59073562; US 4613695

Piroxicam pivalate, CHF-10/21, Unicam

特戊酸吡罗昔康Chemical Name: 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-[N-(2-pyridyl)carboxamide] 1,1-dioxide pivalic ester; 2,2-Dimethylpropionic acid 2-methyl-3-[N-(2-pyridyl)carbamoyl]-2H-1,2-benzothiazin...
参考文献标题:Benzo-1,2-thiazine 1,1-dioxide derivs.,their preparation and their use
文献作者:Chiesi,P.; Villani,F.(Chiesi Farmaceutici SpA)
参考来源:BE 0895712; EP 0085866