Nicaraven, AVS, Antevas
烟拉文Chemical Name: 1,2-Bis(nicotinamido)propane; N-N'-(1-Methyl-1,2-ethanediyl)bis-3-pyridinecarboxamide
CAS No. 79455-30-4
项目整合开发状态: Pre-Registered
项目研究机构: Chugai (Originator), Novartis (Comarketer)
合成路线:This compound can be obtained by three different ways:1) By condensation of nicotinoyl chloride (I) with 1,2-diaminopropane (IV) by means of triethylamine in pyridine.2) By reaction of nicotinic acid (II) with 1,2-diaminopropane (IV) by means of ethyl chloroformate and triethylamine in THF.3) By heating at 120 C a mixture of methyl nicotinate (III) with 1,2-diaminopropane (IV).
📌 参考资料/链接：
参考文献标题:Nicotinamide derivative,process dor preparing the same and pharmaceutical composition containing the same
文献作者:Mori,T.; Takaku,S.; Matsuura,F.; Murakami,Y.; Noda,Y.; Yamazaki,T.; Neichi,T.; Nakakimura,H.; Kataoka,S.(Chugai Pharmaceutical Co.Ltd.)
参考来源:EP 0029602; JP 56075474
📄 详细内容
合成路线:This compound can be obtained by three different ways:1) By condensation of nicotinoyl chloride (I) with 1,2-diaminopropane (IV) by means of triethylamine in pyridine.2) By reaction of nicotinic acid (II) with 1,2-diaminopropane (IV) by means of ethyl chloroformate and triethylamine in THF.3) By heating at 120 C a mixture of methyl nicotinate (III) with 1,2-diaminopropane (IV).
参考文献标题:AVS
文献作者:Grau,M.; Serradell,M.N.; Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1983,8(6),485
产品链接: CAS No. 79455-30-4››