项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Azurene, Bromperidol, R-11333, Impromen

溴哌利多Chemical Name: 4-[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
CAS No. 10457-90-6, 59453-24-6 (HCl)
项目整合开发状态: Launched-1981
项目研究机构: Janssen (Originator), Forme...
参考文献标题:Synthesis of [82Br]bromperidol and preliminary tissue distribution studies in the rat
文献作者:Vincent,S.H.; Shambhu,M.B.; Digenis,G.A.
参考来源:J Med Chem 1980,23(1),75

Broperamole, TR-2378

溴哌莫Chemical Name: 1-[3-[5-(3-Bromophenyl)-2H-tetrazol-2-yl]propionyl]piperidine
CAS No. 33144-79-5
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The chlorination of 3-[5-(m-bromophenyl)-2H-te...
参考文献标题:Broperamole
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Arrigoni,Martelli,E.
参考来源:Drugs Fut 1981,6(4),214

Brivudine, Bromovinyldeoxyuridine, RP-101, A-176, BVDU, Zostex, Helpin

溴夫定Chemical Name: (E)-5-(2-Bromovinyl)-2'-deoxyuridine
CAS No. 69304-47-8
项目整合开发状态: Launched-2001
项目研究机构: Berlin-Chemie (Originator), Menarini (Originator), Rega Institute for Medical Researc...
参考文献标题:Bromovinyldeoxyuridine
文献作者:De Clercq,E.
参考来源:Drugs Fut 1980,5(7),334

Broxaterol, Z-1170, Summair

溴沙特罗Chemical Name: (?-3-Bromo-alpha-[(tert-butylamino)methyl]-5-isoxazolemethanol
CAS No. 76596-57-1
项目整合开发状态: Registered-1994
项目研究机构: Zambon (Originator)
合成路线:The condensation of 3-bromo-...
参考文献标题:1-(3-Bromo-isoxazol-5-yl)-2-tert-butylaminoethanol
文献作者:Chiarino,D.; Della Bella,D.(Zambon Group SpA)
参考来源:JP 1980108862; US 4276299

Brofaromine hydrochloride, CGP-11305A, Consonar

溴法罗明溴法诺明 Chemical Name: 4-(7-Bromo-5-methoxy-2-benzofuranyl)piperidine hydrochloride
CAS No. 63638-90-4, 63638-91-5 (free base)
项目整合开发状态: Phase III
项目研究机构: Novartis (Originator)
合成路线:Brom...
参考文献标题:Tetrahydropyridine and piperidine derivatives and processes for the preparation thereof
文献作者:Schenker,K.; Bernasconi,R.(Novartis AG)
参考来源:DE 2653147; ES 453582; FR 2332754; GB 1565055; JP 52065277

Brodimoprim, Ro-10-5970, Unitrim, Hyprim

溴莫普林 2,4-嘧啶二胺,5-[(4-溴-3,5-二甲氧基苯基)甲基]-,盐酸盐 (1:) Chemical Name: 2,4-Diamino-5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine; 5-(4-Bromo-3,5-dimethoxybenzyl)-2,4-pyrimidinediamine
CAS No. 56518-41-3, 56518-...
参考文献标题:Benzylpyirimidine derivates
文献作者:Kompis,I.(F.Hoffmann-La Roche AG)
参考来源:CA 1017743; DE 2452889; FR 2250533; GB 1449387; JP 50077378; NL 7414528

Bromerguride, 2-Br-LIS, ZK-95451

溴麦角脲Chemical Name: 3-(2-Bromo-9,10-didehydro-6-methylergolin-8alpha-yl)-1,1-diethylurea; 2-Bromolisuride; (6aR,9S)-N'-[5-Bromo-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinolin-9-yl]-N,N-diethylur...
参考文献标题:Process for the preparation of 2-bromo-8-ergolinyl
文献作者:Bner,H.; Haffer,G.; Sauer,G.(Schering AG)
参考来源:DE 3340025; US 4970314

Pantoprazole sodium, DZ-2352a, B-8510-29(free acid), By-1023/SK&F-96022(free acid), B-8610-23/SK&F-96022-Z, Pantorc, Rifun, Pantozol, Zurcal, Ulcotenal, Inipomp, Pantecta, Anagastra, Pantoloc, Pantopan, Inipomp, Peptazol, Protonix, Protium

潘托拉唑钠泮托拉唑泮托拉唑钠水合物Chemical Name: 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole sodium salt
CAS No. 138786-67-1, 102625-70-7 (free acid), 164579-32-2 (sesquihydr...
参考文献标题:Antisecretory substd.pyridylmethylthio-(or sulfinyl)benzimidazoles
文献作者:Rainer,G.; Riedel,R.; Senn-Bilfinger,J.; Klemm,K.; Schaefer,H.; Figala,V.(Altana Pharma Deutschland GmbH )
参考来源:EP 0134400; JP 1984206379; JP 1993086037; US 4555518

SNC-80

激动剂(含哌嗪基)Chemical Name: (+)-4-[(alphaR)-alpha-[(2S,5R)-4-Allyl-2,5-dimethylpiperazin-1-yl]-3-methoxybenzyl]-N,N-diethylbenzamide
CAS No. 156727-74-1
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithKl...
参考文献标题:Probes for narcotic receptor mediated phenomena.19.Synthesis of (+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A highly selective,nonpeptide delta opioid receptor agonist
文献作者:Calderon,S.N.; Rothman,R.B.; Porreca,F.; Flippen-Anderson,J.L.; McNutt,R.W.; Xu,H.; Smith,L.E.; Bilsky,E.J.; Davis,P.; Rice,K.C.
参考来源:J Med Chem 1994,14(37),2125

Norgestimate, ORF-10131, D-138

炔诺肟酯Chemical Name: (+)-17-Acetoxy-3-ethyl-18,9-dinor-17alpha-pregn-4-en-20-yn-3-one oxime; 17beta-Acetoxy-13beta-ethyl-17alpha-ethynyl-gon-4-en-3-one oxime
CAS No. 35189-28-7
项目整合开发状态: Launched-...
参考文献标题:Norgestimate
文献作者:Hillier,K.; Castar,J.
参考来源:Drugs Fut 1977,2(2),122