合成路线:The condensation of 3-bromo-5-isoxazolylcarbonyl chloride (I) with diethyl malonate (II) gives the corresponding malonyl derivative (III),which is submitted to a decarboxylative hydrolysis yielding 5-acetyl-3-bromoisoxazole (IV).Bromination of (IV) affords 5-(bromoacetyl)-3-bromoisoxazole (V),which is reduced to 2-bromo-1-(3-bromo-5-isoxazolyl)ethanol (VI).Title compound is obtained by reaction of (VI) with tert-butylamine directly or via oxirane (VII),which is obtained by reaction of (VI) with sodium hydride,and finally by reaction of (VII) with tert-butylamine.
参考文献标题:Broxaterol
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1987,12(2),107
合成路线:The condensation of 3-bromo-5-isoxazolylcarbonyl chloride (I) with diethyl malonate (II) gives the corresponding malonyl derivative (III),which is submitted to a decarboxylative hydrolysis yielding 5-acetyl-3-bromoisoxazole (IV).Bromination of (IV) affords 5-(bromoacetyl)-3-bromoisoxazole (V),which is reduced to 2-bromo-1-(3-bromo-5-isoxazolyl)ethanol (VI).Title compound is obtained by reaction of (VI) with tert-butylamine directly or via oxirane (VII),which is obtained by reaction of (VI) with sodium hydride,and finally by reaction of (VII) with tert-butylamine.
参考文献标题:New isoxazole derivatives with a potent and select
文献作者:Fantucci,M.; Sala,R.; Chiarino,D.; Frigeni,V.; Della Bella,D.; Carenzi,A.
参考来源:Farm Sci Ed 1986,41(6),440
产品链接: CAS No. 76596-57-1››